Embryonic early-cleavage rate is decreased with aging in GnRH agonist but not inantagonist protocols

Journal of Assisted Reproduction and Genetics
Wen-Jui YangShun-Yu Hsiao

Abstract

The aim of this study was to evaluate the correlation between embryonic early-cleavage status and the age of patients receiving either a GnRH agonist long protocol or a GnRH antagonist protocol. This retrospective study included 534 patients undergoing a fresh cycle of oocyte retrieval and day-3 embryo transfer. Of the 534 patients treated, 331 received a GnRH agonist long stimulation protocol (GnRH agonist group) for ovarian stimulation and 203 patients received a GnRH antagonist protocol (GnRH antagonist group). By logistic regression analysis, the rate of embryonic early-cleavage was significantly decreased with increasing age of women in the agonist (P < 0.001) but not in antagonist groups (P = 0.61). Based on the results of this study, maternal age is a critical factor for embryonic early-cleavage in agonist protocol but not in antagonist protocol. The results also showed that early-cleavage embryos were of better quality and resulted in a higher pregnancy rate than late-cleavage embryos in the GnRH agonist group. However, embryo quality and pregnancy rate was not significantly different between early and late cleavage embryos in the GnRH antagonist group. We conclude that embryonic early-cleavage status is negatively corr...Continue Reading

References

Apr 1, 1995·Endocrine Reviews·D LeRoithC T Roberts
Aug 1, 1997·Fertility and Sterility·A S Lim, M F Tsakok
May 20, 1999·Molecular Human Reproduction·E M CasañM L Polan
Dec 26, 2001·European Journal of Endocrinology·Carsten GründkerGünter Emons
Oct 17, 2003·Biology of Reproduction·J P de BruinE R te Velde
Jun 21, 2005·Annals of the New York Academy of Sciences·Heng-Kien AuRong-Hong Hsieh
Aug 14, 2012·Physiological Research·D HlinkaM Dudáš

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Citations

Oct 26, 2018·Molecular Reproduction and Development·Won-Jae KimSe-Pill Park
Aug 4, 2017·Human Reproduction Open·UNKNOWN ESHRE Special Interest Group of Embryology, UNKNOWN Alpha Scientists in Reproductive Medicine

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