Embryonic estrogen receptors: do they have a physiological function?

Environmental Health Perspectives
J Gorski, Q Hou

Abstract

In normal estrogen target tissues, estrogen action is mediated through a specific nuclear transcription factor, the estrogen receptor (ER). The site of estrogen action in the developing organism is therefore determined by cells that contain ER and other necessary tissue and gene-specific components for estrogen-mediated transcription. Immunocytochemical methods were used to determine the cellular localization and tissue distribution of ERs in reproductive tracts of mouse fetuses. Nuclear staining for ER was observed in reproductive tracts at fetal days 13 to 15. ERs were present in the precursors of both male and female reproductive tracts at these early developmental stages, which may be attributable to their similar embryonic origins. However, as the tissues undergo sexual differentiation at later fetal and early neonatal ages, ER increases in the female reproductive tracts as compared with the male. ER was detected by immunoblotting on fetal day 10 (before sexual differentiation) in extracts of whole mouse embryos. To determine whether ER and progesterone receptor genes are expressed earlier in development, we examined RNA from preimplantation mouse embryos using reverse transcriptase-polymerase chain reaction techniques. ER...Continue Reading

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Citations

Sep 30, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Yanqin ZhangShie Wang
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Betka, G V Callard
Nov 3, 2010·Expert Review of Endocrinology & Metabolism·Tomoshige KinoGeorge P Chrousos
Jul 3, 2007·Molecular Nutrition & Food Research·Wendy N JeffersonRetha R Newbold
Apr 3, 2016·Development, Growth & Differentiation·Xiaoxiang ChengShie Wang
May 14, 2016·Theriogenology·S BairagiL P Reynolds
Nov 1, 2002·The Journal of Experimental Zoology·Hiroshi UrushitaniTaisen Iguchi
Feb 1, 2007·Physics in Medicine and Biology·Salem AmaraHafedh Abdelmelek
Oct 20, 2018·The Journal of Reproduction and Development·Guoyun WuFangxiong Shi
Mar 27, 2012·The Journal of Reproduction and Development·Hongfeng WangErdogan Memili

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