Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain

Metallomics : Integrated Biometal Science
Jinyoung Lee, Jennifer L Freeman

Abstract

A developmental lead (Pb) exposure has been proposed as an environmental risk factor for adult neurodegenerative diseases including Alzheimer's disease (AD). Recent animal studies showed pathological characteristics of AD in adults with a developmental Pb exposure, but additional studies are needed to investigate this phenomenon. To further assess the relationship between an embryonic Pb exposure and latent neurological alterations, the brain of adult female and male zebrafish aged 12 months that were exposed to a control treatment or 10 μg L(-1) Pb only during embryogenesis (1-72 hours after fertilization) were analyzed on a zebrafish-specific microarray platform. Gene ontology and pathway analysis revealed similarities in the top disease and functional categories in both sexes, but females had 4.3 times more genes altered than males. In addition, alterations in genes associated with nervous system development and function were more pronounced with a set of 89 genes associated with AD including amyloid precursor protein (APP), apolipoprotein (APOE), and sortlin-related receptor precursor (SORL1) observed to be changed in adult females. Our observations suggest that an embryonic exposure to Pb at levels as low as 10 μg L(-1) di...Continue Reading

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Citations

Jun 5, 2016·Metallomics : Integrated Biometal Science·Rachel Narehood AustinTomás R Guilarte
Nov 28, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Miguel Chin-ChanMaria Ermolaeva
Dec 5, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Adrian J Green, Antonio Planchart
Sep 17, 2017·Neuroscience and Biobehavioral Reviews·Nathana J MezzomoDenis B Rosemberg
Jun 23, 2020·Chemical Research in Toxicology·Jinyoung Lee, Jennifer L Freeman

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