Embryonic expression of the cysteine rich protein 61 (CYR61) gene: A candidate for the development of human epispadias

Birth Defects Research. Part A, Clinical and Molecular Teratology
Markus DraakenMichael Ludwig

Abstract

Isolated epispadias is the mildest phenotype of the exstrophy-epispadias complex, a urogenital birth defect of variable severity. The androgen receptor antagonist flutamide (FLU) is known to cause malformations in the rat genital and reproductive tract, and single-dose prenatal FLU exposure can induce epispadias in rat offspring. The Cyr61 gene exhibited the highest response to FLU in rat fetal testis, and we suggested it a promising candidate gene for epispadias in humans, because its protein product promotes proliferation, migration, and adhesion of endothelial cells and fibroblasts. We used whole mount in situ analysis in mice to investigate ventrocaudal expression of the Cyr61 transcript at gestational days 9.5 to 11.5, which is the equivalent of human gestational weeks 4 to 6 (postulated time of epispadias organogenesis in humans). We also performed mutational analysis of the CYR61 gene in 11 patients with isolated epispadias and in additional eight patients with the related classic bladder exstrophy phenotype. Expression of Cyr61 was detected in endothelial cells of vessels surrounding the cloaca and the umbilical cord on gestational days 10 and 11.5. The mutation screening, however, revealed no alterations in the coding ...Continue Reading

References

Aug 1, 1979·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R O'Rahilly
May 1, 1992·The Journal of Urology·L J Van Bogaert
Aug 1, 1984·The Journal of Urology·E ShapiroR D Jeffs
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·E Diamanti-KandarakisA J Duleba
Feb 29, 2000·Journal of Medical Screening·J K Morris, N J Wald
Mar 17, 2001·American Journal of Medical Genetics·J C Carey
Feb 13, 2002·Oncogene·Miaw-Sheue TsaiRuth Lupu
Nov 26, 2002·Molecular and Cellular Biology·Fan-E MoLester F Lau
Jul 2, 2003·American Journal of Medical Genetics. Part a·Heiko ReutterJeffrey R Gruen
Jan 28, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jeanne M Manson, Michael C Carr
Apr 17, 2004·Advances in Experimental Medicine and Biology·Laurence S Baskin
May 27, 2004·Gene Expression Patterns : GEP·Ulrike RichterMichael Kessel
Aug 18, 2004·The Urologic Clinics of North America·Aseem R ShuklaDouglas A Canning
Aug 27, 2004·BJU International·Lee AllenJohn M Hutson
Mar 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paul M D Foster, Martha W Harris
Apr 18, 2007·The Journal of Urology·Zhong WangLaurence S Baskin
Oct 17, 2007·American Journal of Medical Genetics. Part a·Heiko ReutterSimeon A Boyadjiev
Apr 16, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ping KangJames A Nieman
Jul 1, 2008·Pediatric Surgery International·Victoria KrügerMichael Ludwig
Jan 24, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Michael LudwigSimeon A Boyadjiev
Apr 16, 2009·The Journal of Reproduction and Development·Thuy T B VoEui-Bae Jeung
May 27, 2009·Trends in Cardiovascular Medicine·Elizabeth McNally, Lisa Dellefave

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