Embryonic growth inhibition induced by cocaine is associated with the suppression of ornithine decarboxylase activity

Proceedings of the Society for Experimental Biology and Medicine
L P Sandstrom, S N Pennington

Abstract

Cocaine use during pregnancy results in significant increases in fetal morbidity and mortality. Multiple maternal and environmental variables influence the fetal response to cocaine, and growth suppression of the developing child is frequently associated with in utero cocaine exposure. Using intact chick embryos as well as cultured embryonic tissue as a model, we report that the growth suppression induced by cocaine exposure is correlated with molecular changes occurring directly in the embryonic cells and that these molecular changes appear to be distinct from other maternal, placental, or environmental effects of the drug, including anoxia. Specifically, embryonic cocaine exposure suppresses the normal developmental increase in ornithine decarboxylase (ODC) enzymatic activity. The loss of ODC activity during the early stages of development is dose dependent and is correlated with the degree of growth suppression. The cocaine-induced loss of decarboxylase activity is specific to ODC, but cocaine, per se, has no effect on ODC activity in vitro. Moreover, a single dose of exogenous putrescine given at 120 hr of incubation blocks the cocaine-induced growth suppression. In cultured embryonic tissue, cocaine exposure inhibits the a...Continue Reading

Citations

Dec 16, 1994·Brain Research. Developmental Brain Research·S N PenningtonL W Means
Nov 1, 1996·Respiration Physiology·J W LiptonD E Weese-Mayer
Nov 25, 1997·Brain Research. Developmental Brain Research·L W EcksteinS N Pennington
Jan 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·D LamosováM Vaneková
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·S N PenningtonJ L Morgan

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