Embryonic Pax7-expressing progenitors contribute multiple cell types to the postnatal olfactory epithelium.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Barbara MurdochMartín I García-Castro

Abstract

Prolonged neurogenesis driven by stem/progenitor cells is a hallmark of the olfactory epithelium (OE), beginning at the placodal stages in the embryo and continuing throughout adult life. Despite the progress made to identify and study the regulation of adult OE progenitors, our knowledge of embryonic OE precursors and their cellular contributions to the adult OE has been stalled by the lack of markers able to distinguish individual candidate progenitors. Here we identify embryonic OE Pax7+ progenitors, detected at embryonic day 10.5 (E10.5) in the olfactory pit with an antigen profile and location previously assigned to presumptive OE stem cells. Using Cre-loxP technology (Pax7-cre/ROSA YFP mice), we expose a wide range of derivatives, including CNS and olfactory neurons, non-neuronal cells, and olfactory ensheathing glia, all made from embryonic Pax7+ cells. Importantly, the expression of Pax7 in the embryonic OE is downregulated from E15.5, such that after birth, no Pax7+ cells are found in the OE, and thus the progenitor population here identified is restricted to embryonic stages. Our results provide the first evidence for a population of Pax7-expressing embryonic progenitors that contribute to multiple OE lineages and dem...Continue Reading

References

Jan 1, 1984·Progress in Neurobiology·T V GetchellM L Getchell
Oct 24, 1998·The Journal of Comparative Neurology·J M HuardJ E Schwob
Sep 12, 2000·Current Opinion in Neurobiology·C Dulac
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I L WeissmanF Gage
Mar 14, 2002·The Anatomical Record·James E Schwob
Oct 16, 2003·Genomics·Deborah LangJonathan A Epstein
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Feb 3, 2004·The Journal of Comparative Neurology·Xueyan ChenJames E Schwob
May 11, 2004·Genes & Development·Frédéric RelaixMargaret Buckingham
Jun 25, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lindsay A CarterA Jane Roskams
Sep 9, 2004·Brain, Behavior and Evolution·Kathleen E Whitlock
Feb 16, 2005·Developmental Neuroscience·Shimako KawauchiAnne L Calof
Jun 1, 2005·Experimental Cell Research·Crestina L BeitesAnne L Calof
Mar 1, 2006·Anatomy and Embryology·Anthony OttoKetan Patel
May 12, 2006·Nature·Martín L BaschMartín I García-Castro
Jul 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandra L Joyner, Mark Zervas
Aug 15, 2006·Biochemical Pharmacology·Deborah LangBruce A Ruggeri
Mar 8, 2007·Nature Reviews. Neuroscience·Geoffrey Raisman, Ying Li
Apr 3, 2007·Developmental Biology·Sophie Bel-VialarFabienne Pituello
May 1, 2007·Nature Neuroscience·Cheuk T LeungRandall R Reed
Jun 2, 2007·Cell·Shihuan KuangMichael A Rudnicki
Jul 24, 2007·Experimental Neurology·Miranda W Richter, A Jane Roskams
Sep 14, 2007·Journal of Molecular Histology·Barbara Murdoch, A Jane Roskams
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Barbara Murdoch, A Jane Roskams
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cynthia D DugganJohn Ngai
Sep 20, 2008·Stem Cells·Darko BosnakovskiMichael Kyba
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Judith A BlakeMelanie Ziman
Nov 26, 2008·Development·Sujata Bhattacharyya, Marianne Bronner-Fraser
Feb 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jane Khudyakov, Marianne Bronner-Fraser

❮ Previous
Next ❯

Citations

Jul 10, 2012·Molecular Neurobiology·Paolo E Forni, Susan Wray
Aug 1, 2012·PloS One·Barbara MurdochMartín I García-Castro
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paolo E ForniSusan Wray
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paolo Emanuele ForniSusan Wray
Dec 19, 2012·Cellular and Molecular Life Sciences : CMLS·Zhidong LuanMartín I García-Castro
Dec 3, 2014·Developmental Biology·Samantha J Butler, Marianne E Bronner
Sep 21, 2011·Progress in Neurobiology·Jennifer A Thompson, Mel Ziman
Dec 26, 2012·Developmental Biology·Crystal D RogersMarianne E Bronner
Sep 25, 2012·Developmental Biology·Nathan Yardley, Martín I García-Castro
Dec 11, 2013·Developmental Biology·Andrew K Groves, Carole LaBonne
Jul 9, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joseph Wai Keung KamJean-François Cloutier
Apr 4, 2012·Current Protocols in Neuroscience·Ulrike Klenke, Carol Taylor-Burds
Dec 29, 2020·Frontiers in Physiology·Ankita Thawani, Andrew K Groves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Perrine BarraudClare V H Baker
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Paolo Emanuele ForniSusan Wray
Annual Review of Cell and Developmental Biology
Paola BetancurTatjana Sauka-Spengler
© 2021 Meta ULC. All rights reserved