Embryonic stem cell miRNAs and their roles in development and disease.

Seminars in Cancer Biology
Joana Alves Vidigal, Andrea Ventura

Abstract

MicroRNAs have emerged as important modulators of gene expression. Both during development and disease, regulation by miRNAs controls the choice between self-renewal and differentiation, survival and apoptosis and dictates how cells respond to external stimuli. In mouse pluripotent embryonic stem cells, a surprisingly small set of miRNAs, encoded by four polycistronic genes is at the center of such decisions. miR-290-295, miR-302-367, miR-17-92 and miR-106b-25 encode for miRNAs with highly related sequences that seem to control largely overlapping gene sets. Recent studies have highlighted the importance of these miRNAs in the maintenance of 'stemness' and regulation of normal development and have linked the deregulation of their expression to a variety of human diseases.

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Citations

Aug 21, 2014·Genes·Lorna W Harries
Mar 19, 2013·Journal of Molecular Biology·Allan M Gurtan, Phillip A Sharp
Nov 12, 2016·Journal of Experimental & Clinical Cancer Research : CR·Xi ZhangXiaowu Li
May 9, 2015·Circulation Research·Conrad P HodgkinsonVictor J Dzau
Jan 25, 2019·Current Stem Cell Research & Therapy·Maryam FarzanehSeyed E Khoshnam
Oct 17, 2018·Frontiers in Molecular Neuroscience·Irene Lacal, Rossella Ventura

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