Embryonic stem cells: An alternative approach to developmental toxicity testing.

Journal of Pharmacy & Bioallied Sciences
S Tandon, S Jyoti

Abstract

Stem cells in the body have a unique ability to renew themselves and give rise to more specialized cell types having functional commitments. Under specified growth conditions, these cell types remain unspecialized but can be triggered to become specific cell type of the body such as heart, nerve, or skin cells. This ability of embryonic stem cells for directed differentiation makes it a prominent candidate as a screening tool in revealing safer and better drugs. In addition, genetic variations and birth defects caused by mutations and teratogens affecting early human development could also be studied on this basis. Moreover, replacement of animal testing is needed because it involves ethical, legal, and cost issues. Thus, there is a strong requirement for validated and reliable, if achievable, human stem cell-based developmental assays for pharmacological and toxicological screening.

Citations

May 27, 2015·Toxicology and Applied Pharmacology·Xiugong GaoJeffrey J Yourick
Oct 15, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jessica A PalmerFred R Kirchner
Sep 26, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Evi StrubleBelay Tesfamariam
Jul 27, 2017·Journal of Biomedical Materials Research. Part a·Thomas S WilemsLaura A Smith Callahan
Dec 12, 2018·Expert Opinion on Drug Metabolism & Toxicology·Ágota ApátiBalázs Sarkadi
Apr 13, 2017·Journal of Nanobiotechnology·Xiugong GaoJeffrey J Yourick

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Methods Mentioned

BETA
Assay
ELISA
genetic modifications
fluorescence-activated cell sorting
FACS
flow cytometry

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