PMID: 9443051Jan 27, 1998Paper

Embryonic stem cells and hematopoietic stem cell biology

Hematology/oncology Clinics of North America
M J Weiss

Abstract

Two advances in murine embryonic stem (ES) cell technology and their applications for the study of hematopoietic stem cells (HSCs) are discussed in this article. First, ES cells induced to differentiate in vitro form hematopoietic lineages in a fashion that recapitulates the ontogeny of blood formation in the embryo. This system offers a unique opportunity to isolate, examine, and manipulate the most primitive hematopoietic progenitors. Second, targeted gene ablation (knockout) studies in ES cells have identified several genes that are required for normal hematopoiesis and may function in the formation, maintenance, and differentiation of HSCs. Insights into murine hematopoiesis gained through the study of ES cells generally should be applicable to other vertebrates, including humans.

References

Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·I L WeissmanW Raschke
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J C Gutierrez-Ramos, R Palacios
May 1, 1992·Molecular and Cellular Biology·R M MortensenJ G Seidman
Apr 1, 1992·Current Opinion in Immunology·G Keller
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J F TolesJ E Barker
Jun 16, 1989·Science·M R Capecchi
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Sep 1, 1995·Trends in Genetics : TIG·E Dzierzak, A Medvinsky
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·L RobbC G Begley
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·R PalaciosJ Samaridis
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·I GodinA Cumano
Jan 1, 1993·Molecular and Cellular Biology·G KellerM V Wiles
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J ChenF W Alt
Dec 1, 1995·International Journal of Hematology·H E BroxmeyerD B Donner
Feb 1, 1996·The Journal of Clinical Investigation·M J Weiss, S H Orkin
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q WangN A Speck
Jan 1, 1995·Annual Review of Cell and Developmental Biology·W Risau, I Flamme
Aug 8, 1996·Nature·K GalaktionovD Beach

❮ Previous
Next ❯

Citations

May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J K DivineD I Gottlieb
Apr 27, 2001·Mechanisms of Ageing and Development·M S Rao, M P Mattson
Jan 1, 2008·Biotechnology & Genetic Engineering Reviews·Yukio Nakamura
May 27, 2006·Experimental Hematology·Takashi HiroyamaYukio Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.