Embryonic stem cells as a novel cell source of cell-based biosensors

Biosensors & Bioelectronics
Qingjun LiuPing Wang

Abstract

To investigate the use of embryonic stem cells as biosensor elements, mouse embryoid bodies were cultured on the surface of the light-addressable potentiometric sensor and induce to in vitro differentiate into cardiomyocytes and neurons. Extracellular potentials of the cells were recorded by sensor, to detect stem cells potential applications in drugs screening. The experimental results show that known cardiac stimulants (isoproterenol) and relaxants (carbamylcholine) have characteristic effects on the cardiomyocytes in terms of the changes of beat frequency, amplitude and duration. Thus, the embryonic stem cells potentially represent a renewable cell source for the cell-based biosensors.

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Citations

Mar 31, 2012·Future Medicinal Chemistry·A WickendenG Erdemli
May 6, 2010·Journal of Zhejiang University. Science. B·Qing-Jun LiuPing Wang
Sep 10, 2016·Journal of Medical Engineering & Technology·Yi Jun TehUda Hashim
Jul 4, 2018·Current Stem Cell Research & Therapy·Amit Alexander Ajazuddin
Jan 1, 2014·Current Protocols in Pharmacology·Alan D Wickenden
Jun 8, 2017·Proceedings. Mathematical, Physical, and Engineering Sciences·Fan WuSteffi Krause
Sep 23, 2021·ACS Synthetic Biology·Fatemeh GhorbaniAmmar Ebrahimi

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