Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions.

American Journal of Physiology. Heart and Circulatory Physiology
Paul R CrisostomoDaniel R Meldrum

Abstract

Stem cell treatment may positively influence recovery and inflammation after shock by multiple mechanisms, including the paracrine release of protective growth factors. Embryonic stem cells (ESCs) are understudied and may have greater protective power than adult bone marrow stem cells (BMSCs). We hypothesized that ESC paracrine protective mechanisms in the heart (decreased injury by enhanced growth factor-mediated reduction of proinflammatory cytokines) would be superior to the paracrine protective mechanisms of the adult stem cell population in a model of surgically induced global ischemia. Adult Sprague-Dawley rat hearts were isolated and perfused via Langendorff model. Hearts were subjected to 25 min of warm global ischemia and 40 min of reperfusion and were randomly assigned into one of four groups: 1) vehicle treated; 2) BMSC or ESC preischemic treatment; 3) BMSC or ESC postischemic treatment; and 4) BMSC- or ESC-conditioned media treatment. Myocardial function was recorded, and hearts were analyzed for expression of tissue cytokines and growth factors (ELISA). Additionally, ESCs and BMSCs in culture were assessed for growth factor production (ELISA). ESC-treated hearts demonstrated significantly greater postischemic recov...Continue Reading

References

Sep 1, 1996·Journal of Clinical Immunology·A C FuchsC A Dinarello
Apr 8, 1998·The American Journal of Physiology·D R Meldrum
Dec 18, 2001·Journal of Applied Physiology·Jiang-Yong MinYong-Fu Xiao
Nov 20, 2002·Journal of the American College of Surgeons·Christopher D RaeburnAlden H Harken
Jul 16, 2003·Circulation·Frederick M RauscherDoris A Taylor
Feb 7, 2004·Circulation Research·Robert LanzaPiero Anversa
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Denice M HodgsonAndre Terzic
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Shaolong YangIrshad H Chaudry
Nov 17, 2004·Molecular and Cellular Biochemistry·Nilanjana Maulik
Feb 28, 2006·Journal of Molecular and Cellular Cardiology·Shaolong YangIrshad H Chaudry
Apr 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Massimiliano GnecchiVictor J Dzau
May 27, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Meijing WangDaniel R Meldrum
Jun 16, 2006·American Journal of Physiology. Cell Physiology·Alicia RiveraCarlo Brugnara
Sep 28, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Timothy J NelsonJohn W Lough
Oct 7, 2006·Journal of Applied Physiology·Christian P SchneiderIrshad H Chaudry
Nov 15, 2006·Journal of Molecular and Cellular Cardiology·Shunsuke OhnishiNoritoshi Nagaya
Dec 26, 2006·Journal of Molecular and Cellular Cardiology·Meifeng XuMuhammad Ashraf
Feb 7, 2007·The Journal of Experimental Medicine·Atta BehfarAndre Terzic
May 19, 2007·Journal of Molecular and Cellular Cardiology·Meijing WangDaniel R Meldrum
Jun 20, 2007·Shock·Paul R CrisostomoDaniel R Meldrum
Jul 21, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Troy A MarkelDaniel R Meldrum
Dec 14, 2007·Critical Care Medicine·Paul R Crisostomo, Daniel R Meldrum
Feb 1, 2008·American Journal of Physiology. Cell Physiology·Paul R CrisostomoDaniel R Meldrum

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Citations

Apr 9, 2010·Journal of Cardiovascular Translational Research·Jeremy L HerrmannDaniel R Meldrum
Jun 19, 2010·Journal of Cardiovascular Translational Research·Husnain Kh Haider, Muhammad Ashraf
Apr 3, 2012·Biologie aujourd'hui·Philippe Menasché
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fan YangDaniel G Anderson
Jul 4, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Lanfang LiJian-Xiong Chen
Feb 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Aaron M AbarbanellDaniel R Meldrum
May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeremy L HerrmannDaniel R Meldrum
Apr 24, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brent R WeilDaniel R Meldrum
Dec 19, 2009·Regenerative Medicine·Nenad BursacBrian Liau
Nov 19, 2010·Regenerative Medicine·Shazia DurraniKhawaja Husnain Haider
Dec 12, 2012·Journal of Biomedicine & Biotechnology·Lucio BarileGiuseppe Vassalli
Aug 15, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·I-Mo FangChung-May Yang
Feb 18, 2016·Stem Cell Research & Therapy·Toru Matsu-uraMuhammad Ashraf
Oct 23, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D CalderonL Chatenoud
Sep 29, 2011·The Annals of Thoracic Surgery·Jeremy L HerrmannDaniel R Meldrum
Sep 11, 2010·The Journal of Surgical Research·Jeremy L HerrmannDaniel R Meldrum
Jan 8, 2010·The Journal of Surgical Research·Aaron M AbarbanellDaniel R Meldrum
Oct 27, 2009·The Annals of Thoracic Surgery·Jeremy L HerrmannDaniel R Meldrum
Dec 24, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Valérie BellamyPhilippe Menasché
Aug 24, 2010·Journal of Molecular and Cellular Cardiology·Maria MirotsouVictor J Dzau
Oct 19, 2010·Journal of the American College of Cardiology·Tim LahmDaniel R Meldrum
Jan 1, 2015·Heart Failure Reviews·Wang ZhaoShui-Ping Zhao
May 20, 2014·European Heart Journal·Philippe MenaschéJérôme Larghero
Nov 7, 2012·Cell Transplantation·Hadhami HamdiPhilippe Menasché
Jan 18, 2014·Circulation Research·Anders Waldenström, Gunnar Ronquist
Jul 23, 2009·Current Opinion in Organ Transplantation·K R VrijsenJ P G Sluijter
Dec 10, 2019·Journal of Cardiovascular Pharmacology·Kurosh AmeriYerem Yeghiazarians
Dec 15, 2018·Advanced Healthcare Materials·Ke HuangKe Cheng
May 15, 2018·Frontiers in Pharmacology·Dongqing GuoXing Chen

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