Embryonic Stem Cells in Development and Regenerative Medicine

Advances in Experimental Medicine and Biology
Ayşegül Doğan

Abstract

After progressive improvement in embryonic stem (ES) cell field, several studies have been conducted to explore the usage of ES cells in regenerative medicine. Unlimited self renewal and pluripoteny properties, combined with encouraging preclinical trials, remark that ES cell technology might be promising for clinical practice. ES cells, which can form three germ layers in vitro, are potential candidates to study development at the cellular and molecular level. Understanding the cell fate decision and differentiation processes during development might enable generating functional progenitor cells for tissue restoration. Progression in gene modifications and tissue engineering technology has facilitated the derivation of desired cells for therapy. Success in differentiation protocols and identification the regulatory pathways simplify the research for clinical applications. Although there are established protocols for cell differentiation in vitro and promising preclinical studies in vivo, many challenges need to be adressed before clinical translation. In this review, ES cells are discussed as a model of development in vitro and as a potential candidate for regenerative medicine. This review also dissusses current challenges fo...Continue Reading

Citations

May 16, 2018·Materials·Ilaria ArmentanoLuigi Torre
Jul 1, 2018·Genes·Francesco MorenaSabata Martino
May 30, 2020·Development·David A Cruz Walma, Kenneth M Yamada
Aug 14, 2020·Acta Biochimica Et Biophysica Sinica·Menghuan GuoHong Zhang
Jan 6, 2021·Developmental Medicine and Child Neurology·Jessica M Sun, Joanne Kurtzberg
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Asim Cengiz AkbulutLeon J Schurgers
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Rong Mu XiaXiu Qin Xu
Aug 8, 2021·International Journal of Molecular Sciences·Margarida ViolaJoost P G Sluijter

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