Embryonic stem cells prevent developmental cardiac defects in mice

Nature Clinical Practice. Cardiovascular Medicine
Diego Fraidenraich, Robert Benezra

Abstract

The potential therapeutic use of embryonic stem cells (ESCs) has gathered the attention of the scientific and medical communities recently. We report that in addition to their unique capacity to populate defective cardiac tissues, ESCs secrete factors that correct gene expression profiles in the defective neighboring cells. Id (inhibitor of DNA binding) gene knockout (KO) mouse embryos die at midgestation because of multiple cardiac defects, but injection of ESCs into preimplantation Id KO embryos prevents these defects and corrects gene expression profiles throughout the heart. ESCs injected into expectant mothers only partially rescue cardiac defects in the Id KO embryos. Two secreted factors are implicated in the rescue process: insulin-like growth factor I accounts for the long-range action of the ESCs, and Wnt5a, a short-range factor, corrects gene expression profiles in the Id KO hearts. Future studies are discussed.

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Citations

Feb 13, 2010·Journal of Cardiovascular Translational Research·Qingshi ZhaoDiego Fraidenraich
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jaime Imitola
May 20, 2011·Pediatric Radiology·Rosalinda T CastanedaHeike Daldrup-Link
Sep 26, 2009·Clinical and Translational Science·Timothy J NelsonAndre Terzic
Aug 2, 2008·Stem Cells·Satsuki YamadaAndre Terzic
Oct 13, 2010·Developmental Biology·Qingshi ZhaoDiego Fraidenraich
Aug 15, 2008·Clinical Pharmacology and Therapeutics·Tj NelsonA Terzic
Sep 18, 2007·Current Opinion in Allergy and Clinical Immunology·Andrea LeonardiLaura Motterle
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Warren ShermanTomasz Siminiak
May 28, 2019·Cell Communication and Signaling : CCS·Wenyu HuYinan Zhao
Feb 3, 2021·International Journal of Cardiology·Fuyi XuYao Sun

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