Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington's disease.

The European Journal of Neuroscience
David Mazzocchi-JonesStephen B Dunnett

Abstract

Embryonic striatal grafts integrate with the host striatal circuitry, forming anatomically appropriate connections capable of influencing host behaviour. In addition, striatal grafts can influence host behaviour via a variety of non-specific, trophic and pharmacological mechanisms; however, direct evidence that recovery is dependent on circuit reconstruction is lacking. Recent studies suggest that striatal grafts alleviate simple motor deficits, and also that learning of complex motor skills and habits can also be restored. However, although the data suggest that such 're-learning' requires integration of the graft into the host striatal circuitry, little evidence exists to demonstrate that such integration includes functional synaptic connections. Here we demonstrate that embryonic striatal grafts form functional connections with the host striatal circuitry, capable of restoring stable synaptic transmission, within an excitotoxic lesion model of Huntington's disease. Furthermore, such 'functional integration' of the striatal graft enables the expression of host-graft bi-directional synaptic plasticity, similar to the normal cortico-striatal circuit. These results indicate that striatal grafts express synaptic correlates of lea...Continue Reading

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Citations

Oct 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniella RylanderBarbara Picconi
Jul 11, 2014·Frontiers in Systems Neuroscience·Naoki TajiriCesar V Borlongan
Feb 1, 2017·Neurochemistry International·Sophie V PreciousAnne E Rosser
Mar 30, 2011·Neurorehabilitation and Neural Repair·David Mazzocchi-JonesStephen B Dunnett
Jul 22, 2010·Neurorehabilitation and Neural Repair·Máté DöbrössyGuido Nikkhah
Jun 29, 2016·Nature Neuroscience·Paolo CalabresiBarbara Picconi
Aug 28, 2020·Frontiers in Cellular Neuroscience·Cristina Salado-ManzanoJosep M Canals
Apr 20, 2019·Frontiers in Molecular Biosciences·Talya ShachamGerardo Z Lederkremer
May 26, 2017·Frontiers in Cell and Developmental Biology·Jea Y LeeSandra A Acosta
Apr 22, 2021·Journal of Neuroscience Research·Margarida BeatrizAna Cristina Carvalho Rego

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