Embryotoxicity in vitro with extract of Indigofera suffruticosa leaves

Reproductive Toxicology
Sônia Pereira LeiteDaniel Eduardo Saul

Abstract

Aqueous extract of leaves of Indigofera suffruticosa (AELIs) were studied for adverse effects in preimplantation mouse embryos. Two-cell mouse embryos were cultured for 94 h in human tubal fluid medium (HTF), and AELIs at a concentration of 5 or 10 mg/ml. On Day 4 of culture, morulae and blastocysts were collected for morphological analysis of blastomeres. We found that embryos exposed to the higher concentration of AELIs (10 mg/ml) did not develop and all embryos persisted at the two-cell stage. Those embryos exposed to the lower concentration (5 mg/ml) showed development until morula, blastocyst and hatched blastocyst stages that were similar to the controls. These results suggest that use of AELIs may be hazardous to humans who make use of it in folk medicine.

References

Dec 1, 1978·Developmental Biology·S Kusunoki, I Yasumasu
Jan 1, 1991·Annual Review of Cell Biology·J R McIntosh, G E Hering
Nov 30, 2000·Theriogenology·W Ji, B D Bavister
May 15, 2001·Phytotherapy Research : PTR·A L ValverdeR M Kuster
May 30, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S BremerM Balls
Jun 12, 2003·Gene Expression Patterns : GEP·Susan LloydJane E Collins
Apr 16, 2008·Tropical Medicine & International Health : TM & IH·Abdullah Al-TaiarChristopher J M Whitty
Aug 25, 2015·Neurología : publicación oficial de la Sociedad Española de Neurología·A Mora-Pérez, M del R Hernández-Medel

❮ Previous
Next ❯

Citations

Aug 9, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Jeymesson Raphael Cardoso VieiraSônia Pereira Leite
Oct 30, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Jeymesson Raphael Cardoso VieiraSônia Pereira Leite
May 23, 2015·Frontiers in Microbiology·Irailton Prazeres Dos SantosVera Lucia de Menezes Lima
Jul 9, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chun-Chieh ChenKai-Li Liu
Feb 17, 2018·Reproduction, Fertility, and Development·Anna Aryani AmirGraeme B Martin
Oct 1, 2020·Acta Cirúrgica Brasileira·Eduardo Alexandre RancanOrlando Castro-E-Silva
Jan 12, 2019·Advances in Pharmacological Sciences·Janaina K L CamposVera L de M Lima
Feb 1, 2020·Journal of Ethnopharmacology·Elise GeromettaAnne Gauvin-Bialecki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Evidence-based Complementary and Alternative Medicine : ECAM
Jeymesson Raphael Cardoso VieiraSônia Pereira Leite
Evidence-based Complementary and Alternative Medicine : ECAM
Sônia Pereira LeiteEdeltrudes de Oliveira Lima
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Tzy-Yen ChenKai-Li Liu
© 2022 Meta ULC. All rights reserved