Embryotoxicity of atrazine and its degradation products to early life stages of zebrafish (Danio rerio)

Environmental Toxicology and Pharmacology
J BlahovaCaterina Faggio

Abstract

Triazine herbicide atrazine is considered to be moderately toxic to various aquatic animals. The aim of our study was to evaluate the acute embryotoxicity of atrazine and its two degradation products, desisopropylatrazine and desethylatrazine, and their mixture to the early life stages of zebrafish (Danio rerio) by means of a modified method of the Fish Embryo Acute Toxicity (FET) Test - OECD guideline 236. Toxic effects were studied by the evaluation of lethal endpoints and development of disorders. Furthermore, sublethal endpoints such as hatching rate, formation of somites, development of eyes, spontaneous movement, heartbeat, blood circulation, pigmentation and occurrence of edema at 24, 48, 72 and 96 h post fertilization were assessed. Newly fertilized eggs were exposed to various concentrations of atrazine, desisopropylatrazine and desethylatrazine, and their combination 0.3, 30, 100, 300, 1000, 3,000 and 10,000 μg/l, which represent environmentally relevant levels of these pollutants in surface waters and multiples of these concentrations to find out if the toxic effect depends on dose. Single substances and their combination were not associated with a negative effect on mortality. Rare malformations were observed during...Continue Reading

Citations

Oct 31, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Heba S HamedCaterina Faggio
Jun 4, 2021·Ecotoxicology and Environmental Safety·Wei YuanHuiqiang Lu
Jun 19, 2021·Environmental Toxicology and Pharmacology·Stefan-Adrian StrungaruCaterina Faggio
Jul 3, 2021·Pharmaceuticals·Roxana JijieCaterina Faggio
Aug 8, 2021·Cells·Karolina NowakWioletta Ratajczak-Wrona
Aug 8, 2021·Veterinary Research Communications·Mohammad Forouhar VajargahCaterina Faggio

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