Embryotoxicity of orally administered chromium in mice: exposure during the period of organogenesis

Toxicology Letters
M JunaidD K Saxena

Abstract

Administration of chromium (VI)(250, 500 and 750 ppm as potassium dichromate) via drinking water during organogenesis (days 6-14 of gestation) in mice revealed embryo- and fetotoxic effects. Reduced fetal weight, retarded fetal development, number of fetuses (live and dead) per mother and high incidences of dead fetuses and resorptions in treated mothers in the highest dosed group were evident. No significant gross structural abnormalities were observed in any of the fetuses of chromium (VI)-treated mothers. Significant incidences of reduced ossification were found in the highest dosed group. Chromium levels were increased in a dose-dependent manner in maternal blood, placenta and fetuses. The present study suggests a risk to the developing embryo if the mother is exposed to a sufficiently high concentration of chromium (VI) through drinking water during the period of organogenesis.

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Citations

Jun 15, 2011·Journal of Physiology and Biochemistry·Nejla SoudaniNajiba Zeghal
Feb 22, 2012·Journal of Physiology and Biochemistry·Nejla SoudaniNajiba Zeghal
Sep 14, 2012·Journal of Physiology and Biochemistry·Nejla SoudaniNajiba Zeghal
Dec 16, 1996·Toxicology Letters·R C MurthyD K Saxena
Dec 31, 1996·Toxicology Letters·R K KanojiaR C Murthy
Aug 15, 1998·Toxicology Letters·R K KanojiaR C Murthy
Jan 6, 2011·Zygote : the Biology of Gametes and Early Embryos·Neila MarouaniKhémais Ben Rhouma
Jan 1, 2011·Journal of Basic and Clinical Physiology and Pharmacology·Kusal K DasSwastika N Das
Sep 24, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Sandhya Mishra, Ram Naresh Bharagava
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Michael DermiencePhilippe Goyens
Mar 25, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mandava V RaoSeema R Sharma
Sep 28, 2013·American Journal of Obstetrics and Gynecology·Tatiana N NanovskayaMahmoud S Ahmed
Mar 8, 2017·Environmental Health : a Global Access Science Source·Linda L RemyTed Clay
Nov 27, 2014·Human & Experimental Toxicology·P SenguptaS Banerjee
May 6, 2011·Toxicology and Industrial Health·Nejla SoudaniNajiba Zeghal
Apr 24, 2015·Toxicology and Industrial Health·Ton YoisungnernJin-Hoi Kim
Nov 9, 2010·Human & Experimental Toxicology·Nejla SoudaniNajiba Zeghal
Jul 20, 2021·The Journal of Reproduction and Development·Yuhe TianChao Zhang
Sep 25, 2021·Environmental Science and Pollution Research International·Sulagna DuttaPallav Sengupta
Nov 17, 2009·Ecotoxicology and Environmental Safety·Nejla SoudaniNajiba Zeghal
May 25, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Nejla SoudaniNajiba Zeghal

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