Emerged HA and NA mutants of the pandemic influenza H1N1 viruses with increasing epidemiological significance in Taipei and Kaohsiung, Taiwan, 2009-10.

PloS One
Chuan-Liang KaoChwan-Chuen King

Abstract

The 2009 influenza pandemic provided an opportunity to observe dynamic changes of the hemagglutinin (HA) and neuraminidase (NA) of pH1N1 strains that spread in two metropolitan areas--Taipei and Kaohsiung. We observed cumulative increases of amino acid substitutions of both HA and NA that were higher in the post-peak than in the pre-peak period of the epidemic. About 14.94% and 3.44% of 174 isolates had one and two amino acids changes, respective, in the four antigenic sites. One unique adaptive mutation of HA2 (E374K) was first detected three weeks before the epidemic peak. This mutation evolved through the epidemic, and finally emerged as the major circulated strain, with significantly higher frequency in the post-peak period than in the pre-peak (64.65% vs 9.28%, p<0.0001). E374K persisted until ten months post-nationwide vaccination without further antigenic changes (e.g. prior to the highest selective pressure). In public health measures, the epidemic peaked at seven weeks after oseltamivir treatment was initiated. The emerging E374K mutants spread before the first peak of school class suspension, extended their survival in high-density population areas before vaccination, dominated in the second wave of class suspension, ...Continue Reading

References

Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Mar 1, 1992·Virus Research·F CiamporA J Hay
Jan 1, 1990·Annual Review of Immunology·I A Wilson, N J Cox
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J W Drake
Aug 2, 2001·Reviews in Medical Virology·M C Zambon
Sep 29, 2001·Journal of Applied Microbiology·C W Potter
Jan 29, 2002·Archives of Virology·E HoffmannD R Perez
Nov 14, 2002·Annual Review of Genetics·David A Steinhauer, John J Skehel
Mar 28, 2003·Nature·Neil M FergusonRobin M Bush
Jul 16, 2004·Journal of Virology·Chang-Won LeeDavid L Suarez
Jun 17, 2006·Proceedings. Biological Sciences·Maciej F BoniMarcus W Feldman
Jan 31, 2007·Nature Reviews. Genetics·Martha I Nelson, Edward C Holmes
Mar 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Arthur Chun-Chieh ShihWen-Hsiung Li
Apr 18, 2008·Nature·Andrew RambautEdward C Holmes
May 3, 2008·PLoS Pathogens·Benjamin P BlackburneRichard A Goldstein
Sep 6, 2008·Vaccine·Maciej F Boni
Sep 11, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shinichi UsuiMotoi Okamoto
Oct 9, 2008·Journal of Molecular Evolution·Baltazar NunesHelena Rebelo-de-Andrade
Feb 28, 2009·BMC Bioinformatics·Jhang-Wei HuangJinn-Moon Yang
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
Mar 3, 2009·Science·Damian C EkiertIan A Wilson
May 9, 2009·The New England Journal of Medicine·Fatimah S DawoodTimothy M Uyeki
May 9, 2009·The New England Journal of Medicine·Mark A MillerLone Simonsen
May 21, 2009·Influenza and Other Respiratory Viruses·Séverine AnsartAlain-Jacques Valleron
May 30, 2009·PLoS Pathogens·Viktor MüllerCarlo Torti
Sep 1, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tzai-Hung WenChwan-Chuen King
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Chi WangChi-Huey Wong
Dec 2, 2009·Journal of Medical Virology·Kelvin K W ToKwok-Yung Yuen
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andrew Mehle, Jennifer A Doudna
Dec 23, 2009·PLoS Currents·Joshua L CherryYuri I Wolf
Dec 24, 2009·PLoS Currents·Martha NelsonKelly Henrickson
Feb 9, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kelvin K W ToKwok-Yung Yuen
Mar 17, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hector M ZepedaRicardo J García-Cavazos

❮ Previous
Next ❯

Citations

Feb 22, 2013·International Journal of Health Geographics·Siddharth ChandraJoshua Vertalka
Oct 27, 2015·Journal of Molecular Modeling·Gema L Ramírez-SalinasJ Correa-Basurto
Feb 14, 2014·Journal of Virology·Hua YangJames Stevens
Jul 31, 2013·PloS One·Alicia Jiménez-AlbertoJuan A Castelán-Vega
Nov 5, 2020·Environment, Development and Sustainability·Mohammad Arif, Soumita Sengupta
Jun 3, 2021·International Journal of Environmental Research and Public Health·Yun JoHyungun Sung
Aug 19, 2021·Journal of Migration and Health·Salma AkterMd Kamal Uddin

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
electrophoresis
glycosylation

Software Mentioned

ArcMap
MacPyMOL
Mega
LISA
ArcGIS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.