Emergence and localized circulation of a vaccine-derived poliovirus in an isolated mountain community in Guangxi, China.

Journal of Clinical Microbiology
Dongmei YanWenbo Xu

Abstract

From March to May 2006, type 1 circulating vaccine-derived poliovirus (cVDPV) was isolated from one case patient with acute flaccid paralysis (AFP) and six unimmunized healthy contacts in isolated mountain villages in Guangxi, China. We conducted epidemiological investigations in the affected communities and nucleotide sequence analyses of the cVDPV isolates. The results of the investigations showed that the AFP patient, an unimmunized 10-year-old boy, and five laboratory-confirmed contacts lived in the same village; one contact lived in a neighboring village. Only approximately 27% of children 5 to 10 years of age in the affected villages had received three or more doses of the trivalent oral poliovirus vaccine (OPV). Nucleotide sequence analyses revealed that the cVDPV isolates differed from the Sabin 1 (S1) isolate at 1.4 to 2.2% of VP1 nucleotide positions and shared 12 nucleotide substitutions within VP1. All isolates were S1/S2/S1/S3 recombinants sharing common recombination junctions. Key determinants of attenuation were replaced. Phylogenetic analysis suggested that the cVDPV circulated locally for approximately 12 months following the initiating OPV dose. No VDPVs were found after mass OPV immunizations, conducted from...Continue Reading

References

Dec 1, 1979·American Journal of Epidemiology·N Nathanson, J R Martin
Oct 1, 1995·Journal of Clinical Microbiology·H G van der AvoortA M van Loon
Feb 1, 1997·The Journal of Infectious Diseases·R B AylwardF Forastiere
Feb 1, 1997·The Journal of Infectious Diseases·K a WangZ Wang
Feb 1, 1997·The Journal of Infectious Diseases·J ZhangK A Wang
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M E ConleyA Etzioni
Sep 27, 1955·Annals of the New York Academy of Sciences·A SHELOKOVD W MCKINSTRY
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Sep 15, 2004·Journal of Clinical Microbiology·David R KilpatrickOlen M Kew
Nov 27, 2004·Journal of Virology·Hiroyuki ShimizuTatsuo Miyamura
Sep 13, 2005·Annual Review of Microbiology·Olen M KewMark A Pallansch
Aug 10, 2006·The Journal of Infectious Diseases·Xiaofeng LiangJingjin Yu
Jan 18, 2008·The Journal of Infectious Diseases·Concepción F EstívarizSholah Imari
Apr 19, 2008·The Journal of Infectious Diseases·Mala Rakoto-AndrianariveloJean-Marc Reynes
Dec 19, 2008·The Journal of Infectious Diseases·James P AlexanderUNKNOWN Vaccine-Derived Poliovirus Investigations Group

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Citations

Jun 17, 2011·The Journal of Infectious Diseases·Emily S AbernathyJoseph P Icenogle
Sep 21, 2013·Emerging Infectious Diseases·Nicksy GumedeMarietjie Venter
Oct 16, 2014·The Journal of Infectious Diseases·Cara C BurnsOlen M Kew
Mar 9, 2013·Risk Analysis : an Official Publication of the Society for Risk Analysis·Radboud J Duintjer TebbensKimberly M Thompson
May 16, 2014·Antiviral Research·Rama Devudu PuligeddaKonstantin Chumakov
Dec 11, 2013·Journal of Virological Methods·David R KilpatrickOlen M Kew
Dec 18, 2013·The Science of the Total Environment·Chang Soo LeeJiyoung Lee
May 23, 2014·Clinical and Vaccine Immunology : CVI·Dongmei YanWenbo Xu

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