Emergence and nature of mathematical difficulties in young children with Barth syndrome.

Journal of Developmental and Behavioral Pediatrics : JDBP
Darcy Raches, Michèle M M Mazzocco

Abstract

Barth syndrome (BTHS), a rare X-linked metabolic disorder, is one of the most common known genetic causes of pediatric dilated cardiomyopathy. Advances in the genetic and physical phenotyping of BTHS have surpassed research on its cognitive phenotype. Herein, we expand upon existing knowledge of math difficulties reported for BTHS by evaluating the emergence, nature, and trajectory of mathematics difficulties in this population. We examined neurocognitive performance of 19 young patients from our current and previous studies of BTHS, relative to published normative data. Children completed the Test of Early Mathematics Ability and standardized measures of IQ, visual perception, and vocabulary; executive functions were evaluated by parent report. We focused on subsets of patients to determine whether math difficulties reported for school-aged boys with BTHS appear by preschool (n = 9), whether number sense deficits associated with mathematics learning disability (MLD) are evident in kindergartners with BTHS (n = 10), and whether cognitive skills are stable from preschool to primary school in this population (n = 12). Preschoolers with BTHS had age-appropriate math, vocabulary, spatial, and IQ scores. Age-appropriate performance ...Continue Reading

References

Apr 1, 1992·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·B StraussH Speidel
Dec 1, 1989·Journal of the American College of Cardiology·R R SchallM Jessup
Dec 1, 1983·Journal of the Neurological Sciences·P G BarthM A Sobotka-Plojhar
Aug 15, 2001·American Journal of Medical Genetics·M M Mazzocco, R I Kelley
Jul 26, 2002·Developmental Neuropsychology·Maureen Dennis, Marcia Barnes
Sep 18, 2002·Developmental Neuropsychology·M Darryn SikoraRobert W Butler
Apr 21, 2004·American Journal of Medical Genetics. Part a·Peter G BarthRonald J A Wanders
Nov 1, 1996·Archives of Gerontology and Geriatrics·D AcanforaUNKNOWN CHF Italian Study Investigators
Aug 6, 2005·International Journal of Cardiology·David TanneYehuda Adler
Dec 15, 2005·Cancer·Femke K AarsenCoriene E Catsman-Berrevoets
Jun 7, 2006·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Michèle M M MazzoccoKatarzyna Lesniak-Karpiak
Mar 14, 2007·Journal of Developmental and Behavioral Pediatrics : JDBP·Michèle M M MazzoccoRichard I Kelly
Nov 21, 2007·Developmental Psychology·Greg J DuncanCrista Japel
May 6, 2009·Developmental Psychology·Nancy C JordanMaria N Locuniak
Aug 1, 2005·Learning Disabilities Research & Practice : a Publication of the Division for Learning Disabilities, Council for Exceptional Children·Michèle M M Mazzocco, Richard E Thompson
Mar 2, 2010·Lancet·John Lynn Jefferies, Jeffrey A Towbin
Apr 1, 2009·Children's Health Care : Journal of the Association for the Care of Children's Health·Eric A StorchBarry J Byrne
Feb 3, 2011·Journal of Developmental and Behavioral Pediatrics : JDBP·David C Geary

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Citations

Oct 9, 2012·Current Opinion in Hematology·Josef Finsterer, Marlies Frank
Jan 9, 2021·Molecular and Cellular Biochemistry·Hana M Zegallai, Grant M Hatch
Aug 7, 2021·Journal of Inherited Metabolic Disease·Carolyn TaylorHilary J Vernon
Oct 30, 2021·Journal of Inherited Metabolic Disease·Reid ThompsonHilary J Vernon

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