Emergence and persistence of beta-lactamase-producing bacteria in the upper respiratory tract in children treated with beta-lactam antibiotics

The American Journal of Medicine
I EliassonC Kamme

Abstract

To assess the ecologic impact, in terms of selection of beta-lactamase-producing respiratory tract bacteria, of a single course of peroral beta-lactam antibiotics. One-hundred fifty consecutive children with clinical signs of bacterial respiratory tract infection were randomly assigned to a seven-day course of treatment with either penicillin V, amoxicillin, or cefaclor. Bacteriologic specimens were collected before treatment, at its termination, and at follow-up four weeks later. All three drugs investigated caused a similar increase in beta-lactamase-producing bacteria, both in absolute and relative terms, an increase that persisted over a period of at least one month after completion of treatment. Penicillin V, amoxicillin, and cefaclor all act as selective agents for beta-lactamase-producing bacteria in the upper respiratory tract. Treatment with a peroral beta-lactam antibiotic puts patients at risk of becoming persistent carriers of beta-lactamase-producing bacteria.

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Citations

Apr 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I EliassonS G Waley
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N SinghI R Marino
May 1, 1999·The Pediatric Infectious Disease Journal·N ThraneH T Sørensen
Jan 6, 2001·The Pediatric Infectious Disease Journal·E MelanderS Mölstad
Jan 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·D Albert
Mar 1, 1992·Scandinavian Journal of Primary Health Care·S MölstadC Schalén
Mar 1, 1997·Scandinavian Journal of Primary Health Care·H Cars, A Håkansson

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