Emergence and recovery in children after desflurane and isoflurane anaesthesia: effect of anaesthetic duration

British Journal of Anaesthesia
G R NordmannA R Wolf

Abstract

We hypothesized that increasing duration of inhalation anaesthesia is associated with slower emergence and recovery in children, and that this effect would be less marked with desflurane in comparison with isoflurane. Fifty-four infants and children assigned in groups according to age and expected length of operation were prospectively randomized to receive either isoflurane (I) or desflurane (D) for anaesthesia. After standard induction, the anaesthesia was maintained using an age-related 1.0 minimum alveolar concentration (MAC) equivalent for either agent in air and oxygen. Local analgesia was used as appropriate. End-tidal volatile agent concentration was recorded until extubation. Clinical evaluation of recovery was made by observers, blinded to group allocation. For patients <4 yr of age, the median (95% CI) times in minutes to first movement [5.27 (D), 9.22 (I)], eye opening [9.42(D), 13.3(I)] and extubation [7.18 (D), 12.5 (I)] were significantly shorter (P<0.05) for desflurane. In the group >4 yr of age, the median (95% CI) times in minutes to first movement [4.42 (D), 11.6 (I)], eye opening [8.55(D), 18.0(I)] and extubation [7.08 (D), 16.7 (I)] were significantly shorter (P<0.001) for desflurane. Times to leave recover...Continue Reading

References

Jul 1, 1978·Anesthesia and Analgesia·T L CookE I Eger
Jan 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R H Taylor, J Lerman
Mar 1, 1993·Journal of Clinical Anesthesia·S S AzadJ L Seltzer
Mar 1, 1996·British Journal of Anaesthesia·A R WolfF W Davies
May 23, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M BeaussierA Lienhart
Apr 17, 2004·Paediatric Anaesthesia·Jerrold Lerman
Jan 22, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Alex MacarioDavid Lubarsky
Feb 25, 2005·Anesthesia and Analgesia·Rachel Eshima MckayWarren R Mckay
Aug 24, 2005·Anesthesia and Analgesia·Edmond I Eger, Steven L Shafer

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Citations

May 5, 2007·Current Opinion in Anaesthesiology·Robert Sümpelmann, Wilhelm Alexander Osthaus
May 5, 2007·Current Opinion in Anaesthesiology·Jerrold Lerman
Jun 23, 2009·Journal of Neurosurgical Anesthesiology·Deepak SinghParmod K Bithal
May 30, 2013·Indian Journal of Anaesthesia·S Bala Bhaskar
Nov 3, 2010·Best Practice & Research. Clinical Anaesthesiology·Steven Michael Sale
Apr 25, 2012·Veterinary Anaesthesia and Analgesia·Enzo VettoratoEddie R Clutton
May 12, 2010·Paediatric Anaesthesia·Jerrold LermanUNKNOWN MAPS Investigators Group
Oct 1, 2014·The Journal of International Medical Research·Ji Seon JeongMi Ae Jeong
Jul 3, 2015·The Cochrane Database of Systematic Reviews·Joseph F StandingMarina Waddington
Jul 6, 2019·Clinical Oral Investigations·Masanori TsukamotoTakeshi Yokoyama

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