Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital

Antimicrobial Agents and Chemotherapy
Véronique Leflon-GuiboutMarie-Hélène Nicolas-Chanoine

Abstract

Three types of multidrug-resistant Escherichia coli isolates, called GEN S, GEN R, and AMG S, according to their three different aminoglycoside resistance patterns, were responsible for urinary tract colonization or infection in 87, 12, and 13 new patients, respectively, in a French 650-bed geriatric hospital over a 13-month period. The three E. coli types belonged to the same clone and phylogenetic group (group B2) and had identical transferable plasmid contents (a 120-kb plasmid), beta-lactam and fluoroquinolone resistance genotypes (bla(TEM-1B), bla(CTX-M-15), and double mutations in both the gyrA and the parC genes), and virulence factor genotypes (aer, fyuA, and irp2). They disseminated in the geriatric hospital, where the antibiotics prescribed most often were fluoroquinolones and ceftriaxone, but not in the affiliated acute-care hospital, where isolation precautions were applied to the transferred patients. Thus, E. coli isolates, both CTX-M-type beta-lactamase producers and fluoroquinolone-resistant isolates, might present a new challenge for French health care settings.

References

Mar 1, 1981·Journal of Bacteriology·C I Kado, S T Liu
May 1, 1994·The Journal of Antimicrobial Chemotherapy·S MariotteM H Nicolas
Jan 1, 1996·Clinical Microbiology Reviews·L E NicolleR A Garibaldi
Feb 1, 1996·Antimicrobial Agents and Chemotherapy·J VilaM T De Anta
Feb 18, 1999·JAMA : the Journal of the American Medical Association·J WienerR A Weinstein
Sep 30, 2000·Applied and Environmental Microbiology·O ClermontE Bingen
Apr 20, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J Y ChenC F Peng
Jul 17, 2001·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·M KomatsuK Shimakawa
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·P A WhiteW D Rawlinson
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E LautenbachN O Fishman
Oct 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M VelascoE Soriano
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·Marcela RadiceGabriel Gutkind
Jan 30, 2002·The Journal of Antimicrobial Chemotherapy·Véronique Leflon-GuiboutMarie-Hélène Nicolas-Chanoine
Jul 12, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ling MaKeizo Yamaguchi
Sep 3, 2002·The Journal of Antimicrobial Chemotherapy·Anna BaraniakMarek Gniadkowski
Feb 4, 2003·The Journal of Antimicrobial Chemotherapy·C NeuwirthR Labia
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·L Armand-LefèvreM-H Nicolas-Chanoine
Apr 4, 2003·International Journal of Antimicrobial Agents·UNKNOWN Members of the SFM Antibiogram Committee
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·E Smith MolandS Pottumarthy
Jul 17, 2003·The Journal of Antimicrobial Chemotherapy·M-F LartigueP Nordmann
Jul 31, 2003·The Journal of Antimicrobial Chemotherapy·Shazad MushtaqDavid M Livermore
Aug 26, 2003·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Patricia Komp LindgrenDiarmaid Hughes
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·R Bonnet

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Citations

Mar 28, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I DamjanovaM Füzi
Nov 13, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L DrieuxV Jarlier
Nov 29, 2012·Foodborne Pathogens and Disease·Sónia RamosPatrícia Poeta
May 5, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Safia DahmenGuillaume Arlet
Dec 7, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Nevine FamMarie-Hélène Nicolas-Chanoine
Feb 22, 2012·Age and Ageing·Xavier BertrandUNKNOWN Réseau des Hygiénistes du Centre
Jan 5, 2013·The Journal of Infectious Diseases·James R JohnsonEvgeni V Sokurenko
Aug 13, 2009·The Journal of Antimicrobial Chemotherapy·Jesús OteoJosé Campos
Nov 13, 2012·The Journal of Antimicrobial Chemotherapy·Marie-Hélène Nicolas-ChanoineVéronique Leflon-Guibout
Sep 20, 2006·Antimicrobial Agents and Chemotherapy·Jean-Philippe LavigneAlbert Sotto
Nov 21, 2007·Antimicrobial Agents and Chemotherapy·Muriel GalasUNKNOWN Collège de Bactériologie Virologie Hygiène (ColBVH) Study Group
Jun 27, 2007·Antimicrobial Agents and Chemotherapy·Corinne ArpinClaudine Quentin
Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Johann D D PitoutJames R Johnson
Nov 17, 2006·Journal of Clinical Microbiology·Jean-Philippe LavigneAlbert Sotto
Dec 31, 2010·Journal of Clinical Microbiology·C Ruiz de AlegríaUNKNOWN Spanish Group for Nosocomial Infections (GEIH)
Mar 13, 2009·PloS One·Jean-Marie PagesMarie-Hélène Nicolas-Chanoine
Feb 3, 2012·PloS One·Marie-Hélène Nicolas-ChanoineUNKNOWN Group Coli β
Sep 12, 2013·PloS One·Marie-Hélène Nicolas-ChanoineUNKNOWN Coli β study group
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Esther CalboJavier Garau
Jan 10, 2014·The Journal of Antimicrobial Chemotherapy·Véronique BlancMarie-Hélène Nicolas-Chanoine
Jan 20, 2012·Diagnostic Microbiology and Infectious Disease·Hemavarna TiruvuryCarl Urban
May 11, 2010·Journal of Molecular Biology·Julien DelmasRichard Bonnet

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