Emergence in Taiwan of novel norovirus GII.4 variants causing acute gastroenteritis and intestinal haemorrhage in children

Journal of Medical Microbiology
Shih-Yen ChenCheng-Hsun Chiu

Abstract

Norovirus is the leading cause of viral gastroenteritis globally. Norovirus genotype GII.4 is responsible for the majority of outbreaks, but new variants are continuously emerging. The objective of the study was to delineate the clinical manifestations and complications associated with these new norovirus GII.4 variants in children. We investigated norovirus infections from the community outbreak in October 2011-September 2012 and an earlier outbreak in 2006-2007, in northern Taiwan. Norovirus genotypes and their variants were validated using molecular methods. A norovirus outbreak started in mid-2011 and continued through 2012 in northern Taiwan. Hospitalized children infected by norovirus in 2012 showed a significantly higher incidence of intestinal haemorrhage, as indicated by grossly bloody faeces (P=0.012) and occult blood in faeces (P < 0.001), and also presented with more high fever >39 °C (P < 0.001), fever >38.5 °C (P < 0.001) and fever of any temperature >38 °C (P < 0.001), compared with children hospitalized in 2006-2007. Analysis of 20 near-full-length genome sequences indicated an emergence of GII.4 2012 variants in 2011-2012. Circulating noroviruses can be divided into two clusters: GII.4 2012a, which is identical...Continue Reading

References

Feb 8, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F MattnerM Koopmans
May 24, 2006·Scandinavian Journal of Gastroenterology·Arne SimonGudrun Fleischhack
Jan 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elise T-V TuPeter A White
Apr 4, 2008·Journal of Virology·Weiming BuRashmi S Hegde
Jun 7, 2008·The Journal of Pediatrics·Reina M Turcios-RuizHelena E Friss
Feb 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shih-Yen ChenCheng-Hsun Chiu
Mar 11, 2009·Journal of Pediatric Gastroenterology and Nutrition·Raheel R KhanJohn N Udall
Jul 25, 2009·The Journal of Infectious Diseases·J Joukje SiebengaMarion Koopmans
Sep 18, 2009·Journal of Virology·Karin BokKim Y Green
Oct 30, 2009·The New England Journal of Medicine·Roger I GlassMary K Estes
Jun 11, 2010·Journal of Virology·Kazushi MotomuraUNKNOWN Norovirus Surveillance Group of Japan
Dec 15, 2010·Journal of Pediatric Gastroenterology and Nutrition·Mi Jin KimYon Ho Choe
Feb 12, 2011·Trends in Microbiology·Rowena A Bull, Peter A White
Jul 1, 2011·Journal of Virology·Denali BoonKarin Bok
Nov 30, 2012·The New England Journal of Medicine·Karin Bok, Kim Y Green
Dec 12, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·T N Hoa TranOsamu Nakagomi
Mar 29, 2013·Journal of Virology·John-Sebastian EdenPeter A White
Jul 28, 2013·Emerging Infectious Diseases·Eyal LeshemAron J Hall

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Citations

Mar 29, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tatiane da Silva PolóAxel Mauroy
Aug 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chung-Chan LeeCheng-Hsun Chiu
Apr 26, 2016·Expert Opinion on Drug Discovery·Sahani WeerasekaraDuy H Hua
Apr 12, 2017·Scientific Reports·Shih-Yen ChenCheng-Hsun Chiu
Jan 30, 2020·Frontiers in Microbiology·Keita OzakiHirokazu Kimura
Jun 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rachel M BurkeAron J Hall

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