Emergence of a functional coupling between inositol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical neurons

Neuroscience
K YamamotoNobuo Kato

Abstract

Cortical pyramidal neurons are considered to be less excitable in the immature cortex than in adults. Our previous report revealed that a negative feedback regulation of membrane excitability is highly correlated with a novel form of calcium release from inositol-1,4,5-trisphosphate (IP(3))-sensitive calcium stores (IP(3)-assisted calcium-induced calcium release) in neocortical pyramidal neurons under muscarinic cholinergic activation. As a step to understand the ground for the low membrane excitability in immature tissue, we examined development of IP(3)-assisted calcium-induced calcium release. In visual cortex neurons from 'juvenile' rats (2-3 weeks of age), an enhancement of spike-frequency adaptation occurred at high spike-frequencies (16-22 Hz), whereas the reduction was observed at low frequencies (6-10 Hz). IP(3)-assisted calcium-induced calcium release occurred at the higher frequencies only. In 'early' postnatal tissue (1 week of age), by contrast, at neither high nor low frequencies did this form of calcium release occur, and muscarinic cholinergic activation always induced a reduction of spike-frequency adaptation at any spike-frequencies. The mechanism for the failure of induction of IP(3)-assisted calcium-induced ...Continue Reading

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Citations

Sep 3, 2010·American Journal of Physiology. Renal Physiology·Sheldon WeinbaumAlan M Weinstein
Sep 30, 2005·The European Journal of Neuroscience·Kenji YamamotoNobuo Kato
Jun 8, 2007·Journal of Neurophysiology·Ryo YamamotoNobuo Kato
Dec 14, 2007·Journal of Neurophysiology·Yoshifumi UetaNobuo Kato
Jun 26, 2003·American Journal of Physiology. Renal Physiology·Craig B WodaLisa M Satlin

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