Emergence of amphotericin B-resistant Cryptococcus laurentii meningoencephalitis shortly after treatment for Cryptococcus neoformans meningitis in a patient with AIDS

AIDS Patient Care and STDs
Roberto ManfrediGianni Fasulo

Abstract

A unique occurrence of two subsequent episodes of HIV-associated Cryptococcus neoformans followed by C. laurentii meningoencephalitis (successfully cured with fluconazole after demonstrated amphotericin B resistance) is presented and discussed. The available literature reported only two cases of HIV-associated C. laurentii infection to date, while a concurrent infection by C. neoformans and C. laurentii has been reported only once in a patient without HIV disease. The absence of prior descriptions of documented central nervous system infection by C. laurentii in non-HIV-infected patients is emphasized as well as the unpredictable in vitro and in vivo antifungal susceptibility of this non-neoformans Cryptococcus spp., and its apparent prevalence in hospitalized patients who received prior antifungal treatments. All epidemiologic, diagnostic, clinical, and therapeutic implications are discussed on the basis of the evolving characteristics of opportunism in the era of highly active antiretroviral therapy (HAART).

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Citations

Feb 25, 2009·AIDS Patient Care and STDs·Manish GopalThomas Klein
Oct 5, 2015·Journal of Industrial Microbiology & Biotechnology·Louis K Ho, Justin R Nodwell
Feb 24, 2007·Carbohydrate Research·John SchutzbachInka Brockhausen
May 25, 2010·Mycoses·Kennio Ferreira-PaimMario León Silva-Vergara
May 9, 2018·Current Opinion in Infectious Diseases·Andrés F Henao-MartínezCarlos Franco-Paredes
Oct 12, 2016·Microbiology Spectrum·Sean X Zhang, Nathan P Wiederhold
May 24, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Juciliane HaidamakDébora do Rocio Klisiowicz

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.