Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins

MBio
Elizabeth J KlemmRumina Hasan

Abstract

Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia and Africa and are often associated with the dominant H58 haplotype. Reduced susceptibility to fluoroquinolones is also widespread, and sporadic cases of resistance to third-generation cephalosporins or azithromycin have also been reported. Here, we report the first large-scale emergence and spread of a novel S Typhi clone harboring resistance to three first-line drugs (chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole) as well as fluoroquinolones and third-generation cephalosporins in Sindh, Pakistan, which we classify as extensively drug resistant (XDR). Over 300 XDR typhoid cases have emerged in Sindh, Pakistan, since November 2016. Additionally, a single case of travel-associated XDR typhoid has recently been identified in the United Kingdom. Whole-genome sequencing of over 80 of the XDR isolates revealed remarkable genetic clonality and sequence conservation, identified a large number of resistance determinants, and showed that these isolates were of haplotype H58. The XDR S Typhi clone encodes a chromosomally located resistance region ...Continue Reading

References

Jan 6, 2001·Journal of Molecular Graphics & Modelling·A R LeachA J Robinson
Feb 13, 2007·Travel Medicine and Infectious Disease·Fiona J Cooke, John Wain
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Oct 1, 2009·Emerging Infectious Diseases·Yvonne PfeiferWolfgang Rabsch
Dec 17, 2009·BMC Bioinformatics·Christiam CamachoThomas L Madden
Jul 14, 2010·Bioinformatics·Lionel GuySiv G E Andersson
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Aug 10, 2011·BMC Genomics·Nabil-Fareed AlikhanScott A Beatson
Mar 19, 2013·International Journal of Medical Microbiology : IJMM·Alessandra Carattoli
May 8, 2013·Antimicrobial Agents and Chemotherapy·Andrew G McArthurGerard D Wright
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
Aug 15, 2014·Journal of Infection in Developing Countries·Farah Naz QamarAnita Kaniz Mehdi Zaidi
Nov 22, 2014·Nucleic Acids Research·Nicholas J CroucherSimon R Harris
Apr 25, 2015·PLoS Neglected Tropical Diseases·Nicholas A FeaseyRobert S Heyderman
Jun 23, 2016·PLoS Neglected Tropical Diseases·Duy Pham ThanhStephen Baker
Sep 16, 2016·Journal of Clinical Microbiology·Marjolein F Q Kluytmans-van den BerghJan A J W Kluytmans
Oct 6, 2016·Nature Communications·Vanessa K WongUNKNOWN International Typhoid Consortium
Mar 1, 2015·Journal of Global Antimicrobial Resistance·Daniela FortiniAlessandra Carattoli
Mar 30, 2017·Microbial Genomics·Andrew J PageSimon R Harris
Jun 9, 2017·PLoS Computational Biology·Ryan R WickKathryn E Holt

❮ Previous
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Citations

Jul 6, 2018·Microbial Genomics·Wim L CuypersSandra Van Puyvelde
Jul 22, 2018·Cellular Microbiology·Rebecca JohnsonGad Frankel
Aug 24, 2018·Current Opinion in Infectious Diseases·Malick M GibaniAndrew J Pollard
Jul 27, 2018·The American Journal of Tropical Medicine and Hygiene·Zulfiqar A BhuttaTikki Pangestu
Jul 27, 2018·The American Journal of Tropical Medicine and Hygiene·Jai K DasZulfiqar A Bhutta
Jan 11, 2019·MMWR. Morbidity and Mortality Weekly Report·Kevin Chatham-StephensCindy R Friedman
Feb 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zulfiqar A Bhutta
Feb 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Megan E CareyA Duncan Steele
Feb 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohammad Tahir YousafzaiRumina Hasan
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zoe A DysonGordon Dougan
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James E MeiringKathleen M Neuzil
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Omari A MsemoJohn P A Lusingu
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James E MeiringMelita A Gordon
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leslie P JamkaKathleen M Neuzil
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samantha KaufholdVirginia E Pitzer
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew J PollardKathleen M Neuzil
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frédéric DebellutClint Pecenka
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christian S MarchelloJohn A Crump
Dec 1, 2018·BMJ : British Medical Journal·Anurag BhargavaEmmanuel Bottieau
Jan 24, 2019·BMJ : British Medical Journal·Christopher M ParryBuddha Basnyat
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth J KlemmGordon Dougan
Mar 17, 2019·American Journal of Epidemiology·Joseph A Lewnard, Arthur L Reingold
Apr 17, 2019·Journal of Medical Microbiology·Megha KaushikPooja Gulati
Mar 6, 2019·The American Journal of Tropical Medicine and Hygiene·Molly E FleeceJames A Platts-Mills
Jun 22, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Khine Mar OoJames E Ussher
Jun 25, 2019·The Medical Journal of Australia·Deborah A WilliamsonDavid L Paterson
Jun 7, 2019·Journal of Clinical Microbiology·Satheesh NairMarie Anne Chattaway
Aug 24, 2019·Nature Microbiology·Sara Hernando-AmadoJosé L Martínez
May 30, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Anne Line EngsbroUffe Vest Schneider
Oct 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claas KirchhelleGordon Dougan
Sep 7, 2018·The Journal of Infectious Diseases·Adwoa D Bentsi-Enchill, Andrew J Pollard
Oct 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Megan E CareyHeidi J Larson
Aug 31, 2019·The Pediatric Infectious Disease Journal·Patricia J SimnerPranita D Tamma
Nov 27, 2019·Health Security·Rana Jawad AsgharAli S Khan
Nov 22, 2019·BMJ Global Health·Richard G MatherSabine Dittrich

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Software Mentioned

Trimmomatic
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BLAST
bcftools

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