Emergence of antiretroviral drug resistance in therapy-naive HIV infected patients in Hungary

Acta Microbiologica Et Immunologica Hungarica
Emese JuhászK Nagy

Abstract

Mutations in the HIV-1 genes associated with resistance to antiretroviral drugs were detected also in primary HIV infected individuals who did not receive antiretroviral treatment. Drug resistance genotyping of HIV pol gene was done by in situ DNA hybridization using a Line Probe Assay and by direct sequencing. Viral variants harbouring resistance mutations such as: M41, T69R, K70R, M184V, T215Y in the pol gene were detected in 14% of the subjects. HIV mutants resistant to NRT inhibitors were found in 10 and 20% of patients infected before and after the year 2000, respectively. Multiple drug resistant viruses (2-3 drug classes) were present in 3.5% of the mainly recently infected patients. In protease gene only minor resistant mutations were found such as L101 and A71V. These findings indicate the evolution of drug resistance showing a correlation with the time of introduction of combination therapy in our country, where more than 70% of HIV infections were by homo/bisexual transmission. This confirms the transmission of drug-resistant HIV shown by genotype testing during primary infection in therapy-naive patients and initiates serious clinical and public health consequences.

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Citations

Apr 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Somnuek SungkanuparphUNKNOWN TREAT Asia Studies to Evaluate Resistance-Monitoring Study (TASER-M)
Dec 17, 2014·Acta Microbiologica Et Immunologica Hungarica·Szilvia KanizsaiKároly Nagy
Dec 1, 2012·Acta Microbiologica Et Immunologica Hungarica·Szilvia KanizsaiKároly Nagy
Mar 31, 2010·Acta Microbiologica Et Immunologica Hungarica·Szilvia KanizsaiK Nagy
May 30, 2008·Acta Microbiologica Et Immunologica Hungarica·Katalin KristófK Nagy
Feb 12, 2010·HIV Medicine·A HaidaraUNKNOWN Appuyer le Traitement Anti Rétroviral en Afrique de l'Ouest (ATARAO) Group 1
Oct 1, 2013·Journal of Marital and Family Therapy·Olga SutherlandAnna Dienhart

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