Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity

The Journal of Clinical Investigation
C GuerraL P Kozak

Abstract

The mRNA levels for the mitochondrial uncoupling protein (UCP1) in fat tissues of A/J and C57BL/6J inbred strains of mice varied in a regional-specific manner after stimulation of adrenergic signaling by cold exposure or treatment with a beta3-adrenergic agonist. While the differences between strains were minimal in interscapular brown fat, large differences occurred in white fat tissues, particularly in retroperitoneal fat. Among the AXB recombinant inbred strains, the Ucp1 mRNA levels varied up to 130-fold. This large induction at the mRNA level was accompanied by a corresponding increase in brown adipocytes as revealed by immunohistology with anti-UCP1 antibodies. A high capacity to induce brown fat in areas of traditional white fat had no impact on the ability to gain weight in response to high fat and sucrose diets, but did correlate with the loss of weight in response to treatment with a beta3-adrenergic agonist (CL 316,243). This genetic variation in mice provides an experimental approach to identify genes controlling the induction of brown adipocytes in white fat tissues.

References

Sep 6, 1979·Nature·N J Rothwell, M J Stock
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·O ChampignyB R Holloway
Sep 1, 1988·Diabetes·R S SurwitM N Feinglos
Nov 1, 1988·Journal of Ultrastructure and Molecular Structure Research·D LoncarB Cannon
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Feb 13, 1984·FEBS Letters·P YoungM Ashwell
Dec 8, 1995·The Journal of Biological Chemistry·V S SusulicB B Lowell
Jan 1, 1993·The Journal of Clinical Investigation·S KriefL J Emorine
Aug 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S HwangB B Knowles
Jun 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Ghorbani, J Himms-Hagen
Jun 9, 1997·Biochemical and Biophysical Research Communications·A Vidal-PuigB B Lowell

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Citations

Dec 1, 2010·Journal of Cardiovascular Translational Research·Manuel MazoFelipe Prosper
Jan 25, 2014·Obesity Research & Clinical Practice·Masayuki Saito
Jun 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Cinti
May 29, 2013·Trends in Endocrinology and Metabolism : TEM·Kanta ChechiDenis Richard
Jul 3, 2013·Trends in Endocrinology and Metabolism : TEM·Mirko Trajkovski, Harvey Lodish
Dec 2, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Silvie HojnaZdenka Pausova
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L P Kozak, R Anunciado-Koza
Mar 11, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L LehrJ-P Giacobino
Oct 12, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L P KozakR Anunciado-Koza
Aug 23, 2008·Nature·Patrick SealeBruce M Spiegelman
Nov 13, 2012·Nature Cell Biology·Mirko TrajkovskiMarkus Stoffel
Apr 30, 2013·Nature Cell Biology·Matthias RosenwaldChristian Wolfrum
Jun 4, 2013·Nature Cell Biology·Youn-Kyoung Lee, Chad A Cowan
May 9, 2012·Nature Medicine·Florian W KieferJorge Plutzky
Apr 23, 2013·Nature Medicine·Martin E LidellSven Enerbäck
Oct 9, 2013·Nature Medicine·Matthew Harms, Patrick Seale
Jun 2, 2010·Nature Reviews. Drug Discovery·Yu-Hua TsengC Ronald Kahn
Oct 23, 2013·Nature Reviews. Endocrinology·Alexander Bartelt, Joerg Heeren
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Del Mar Gonzalez-BarrosoA M Cassard-Doulcier
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Li YeBruce M Spiegelman
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Maria-Jesus Obregon
Jul 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Larissa NikonovaLeslie P Kozak
Feb 18, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Aaron M Cypess, C Ronald Kahn
May 22, 2010·Current Opinion in Pediatrics·Aaron M Cypess, C Ronald Kahn
May 17, 2008·Genes & Development·Shingo KajimuraBruce M Spiegelman
Feb 8, 2013·Genes & Development·Jun WuBruce M Spiegelman
Sep 2, 2005·Molecular and Cellular Biology·Bingzhong XueLeslie P Kozak
Oct 14, 2000·Annual Review of Cell and Developmental Biology·E D Rosen, B M Spiegelman
Aug 15, 2000·Annual Review of Nutrition·L P Kozak, M E Harper

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