Emergence of collective propulsion through cell-cell adhesion

Physical Review. E
Katsuyoshi Matsushita

Abstract

The mechanisms driving the collective movement of cells remain poorly understood. To contribute toward resolving this mystery, a model was formulated to theoretically explore the possible functions of polarized cell-cell adhesion in collective cell migration. The model consists of an amoeba cell with polarized cell-cell adhesion, which is controlled by positive feedback with cell motion. This model cell has no persistent propulsion and therefore exhibits a simple random walk when in isolation. However, at high density, these cells acquire collective propulsion and form ordered movement. This result suggests that cell-cell adhesion has a potential function, which induces collective propulsion with persistence.

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Citations

Jun 25, 2020·Physical Review. E·Katsuyoshi Matsushita
Jan 16, 2021·Physical Review Letters·Tetsuya Hiraiwa

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