Emergence of Different Gaits in Infancy: Relationship Between Developing Neural Circuitries and Changing Biomechanics

Frontiers in Bioengineering and Biotechnology
Arthur Henri DewolfYury Ivanenko

Abstract

How does gait-specific pattern generation evolve in early infancy? The idea that neural and biomechanical mechanisms underlying mature walking and running differ to some extent and involve distinct spinal and supraspinal neural circuits is supported by various studies. Here we consider the issue of human gaits from the developmental point of view, from neonate stepping to adult mature gaits. While differentiating features of the walk and run are clearly distinct in adults, the gradual and progressive developmental bifurcation between the different gaits suggests considerable sharing of circuitry. Gaits development and their biomechanical determinants also depend on maturation of the musculoskeletal system. This review outlines the possible overlap in the neural and biomechanical control of walking and running in infancy, supporting the idea that gaits may be built starting from common, likely phylogenetically conserved elements. Bridging connections between movement mechanics and neural control of locomotion could have profound clinical implications for technological solutions to understand better locomotor development and to diagnose early motor deficits. We also consider the neuromuscular maturation time frame of gaits result...Continue Reading

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Citations

Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Germana CappelliniYury Ivanenko
Jul 16, 2020·Journal of Neurophysiology·G CappelliniY Ivanenko
Jan 14, 2021·European Journal of Applied Physiology·Margit M BachNadia Dominici
Jan 12, 2021·Journal of the Peripheral Nervous System : JPNS·Guido FelicettiMarco Schieppati
Feb 9, 2021·Frontiers in Cellular Neuroscience·Arthur H DewolfFrancesco Lacquaniti
Apr 3, 2021·Frontiers in Bioengineering and Biotechnology·Marine Jequier GygaxJulien Favre
Mar 18, 2021·Journal of Neurophysiology·Vincent C K Cheung, Kazuhiko Seki
Aug 31, 2021·PeerJ·Germán PequeraCarlo M Biancardi
Oct 23, 2021·The Journal of Experimental Biology·Vivian L Rose, Christopher J Arellano

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