Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum-beta-lactamase-producing Escherichia coli among companion animals

The Journal of Antimicrobial Chemotherapy
Christa EwersSebastian Guenther

Abstract

In view of the intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15 extended-spectrum beta-lactamase (ESBL) in human clinical settings it would be of great interest to explore its existence in animals to unravel a possible reservoir function and the origin and transmission of this group of multiresistant strains. A total of 177 clinical phenotypically ESBL-producing E. coli isolates, mainly obtained from companion animals with urinary tract infections, wound infections and diarrhoea, were collected in a veterinary diagnostic laboratory covering a European-wide service area. They were screened for molecular subtype O25b and multilocus sequence type 131. O25b-ST131 isolates were subsequently tested for ESBL types, and phenotypic and genotypic resistance determinants. Further characterization of the strains was performed by PFGE and virulence gene typing. Ten (5.6%) of 177 phenotypically ESBL-producing E. coli isolates, nine strains from dogs and one strain from a horse, were allocated to the B2-O25b-ST131 lineage. Nine of these isolates harboured a CTX-M-15-type beta-lactamase enzyme while one strain possessed an SHV-12-type ESBL. Macrorestriction analysis revealed a cluster formation of six of the...Continue Reading

References

Mar 31, 1998·Lancet·L Martínez-MartínezG A Jacoby
Jul 4, 2002·The Journal of Antimicrobial Chemotherapy·Frédéric BertNicole Lambert-Zechovsky
Jul 17, 2004·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B GuerraM C Mendoza
Aug 7, 2004·Journal of Clinical Microbiology·Verena GrimmTill T Bachmann
Feb 12, 2005·Emerging Infectious Diseases·Catherine BrangerErick Denamur
Feb 22, 2005·Veterinary Research·Kylie E Rodriguez-SiekLisa K Nolan
Jun 7, 2005·Journal of Microbiological Methods·Alessandra CarattoliE John Threlfall
Jul 16, 2005·The Journal of Antimicrobial Chemotherapy·Patrice Nordmann, Laurent Poirel
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·Ulrich Dobrindt
Nov 5, 2005·Applied and Environmental Microbiology·Patrick BoerlinMarie Archambault
May 13, 2006·Molecular Microbiology·Thierry WirthMark Achtman
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·A RobicsekD C Hooper
Sep 1, 2006·Current Opinion in Microbiology·Rafael Cantón, Teresa M Coque
Sep 7, 2006·Antimicrobial Agents and Chemotherapy·Chi Hye ParkDavid C Hooper
Dec 13, 2006·The Journal of Antimicrobial Chemotherapy·David M LivermoreNeil Woodford
Dec 14, 2007·The Journal of Antimicrobial Chemotherapy·Marie-Hélène Nicolas-ChanoineJames R Johnson
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Carattoli
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R CantónT M Coque
Mar 13, 2008·The Journal of Antimicrobial Chemotherapy·Olivier ClermontGuillaume Arlet
Nov 14, 2008·The Journal of Antimicrobial Chemotherapy·Satowa SuzukiYoshichika Arakawa
May 26, 2009·International Journal of Antimicrobial Agents·Jesús OteoUNKNOWN Spanish Network in Infectious Pathology Project (REIPI)

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Citations

Dec 8, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Bjorn J A BerendsenMichel W F Nielen
Feb 2, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Umaer Naseer, Arnfinn Sundsfjord
May 27, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Miranda KirchnerChristopher Teale
Oct 26, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Anna MarcheseEugenio Debbia
Jun 24, 2010·The Journal of Antimicrobial Chemotherapy·Joanne L PlatellDarren J Trott
Nov 18, 2010·The Journal of Antimicrobial Chemotherapy·Benjamin A RogersDavid L Paterson
Jan 3, 2012·The Journal of Antimicrobial Chemotherapy·Jean-Yves MadecMarisa Haenni
Apr 20, 2013·The Journal of Antimicrobial Chemotherapy·Anne-Kathrin SchinkStefan Schwarz
Jul 9, 2013·The Journal of Antimicrobial Chemotherapy·Inka StolleChrista Ewers
Jul 16, 2013·The Journal of Antimicrobial Chemotherapy·Safia DahmenJean-Yves Madec
Jun 21, 2011·Applied and Environmental Microbiology·Anne-Kathrin SchinkStefan Schwarz
Jun 28, 2011·Applied and Environmental Microbiology·Margarita Martinez-MedinaChrista Ewers
Feb 19, 2013·Applied and Environmental Microbiology·Elisabeth HauserHerbert Schmidt
May 23, 2012·Emerging Infectious Diseases·Hilde De BoeckJan Jacobs
Mar 1, 2014·Veterinary Microbiology·Joseph E Rubin, Johann D D Pitout
Apr 9, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Torahiko OkuboYutaka Tamura
May 7, 2014·The Journal of Antimicrobial Chemotherapy·G C A AmosE M Wellington
Jun 30, 2014·The Journal of Antimicrobial Chemotherapy·Christa EwersAstrid Bethe
Feb 27, 2014·The Veterinary Record·D TimofteN J Williams

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