Emergence of Klebsiella pneumoniae subspecies pneumoniae as a cause of septicaemia in pigs in England

PloS One
Cornelia A BidewellManal AbuOun

Abstract

Between 2011 and 2014 outbreaks of septicaemia due to Klebsiella pneumoniae subspecies pneumoniae (Kpp) were diagnosed on thirteen English pig farms. The most consistent features were rapid deaths of pigs from ten-days-old to weaning, seasonal occurrence (May to September), affected farms being outdoor breeding herds and the location of all but one of the outbreaks in the East Anglia region in Eastern England. Molecular characterisation of the outbreak Kpp isolates showed that by multilocus sequencing all were sequence type 25 (ST25) of K2 capsular type with a combination of a 4.3kb plasmid (pKPMC25), three phage sequences and the rmpA virulence gene. No archived Kpp isolates of porcine origin pre-dating 2011 were identified as ST25. In 2013 there was the first detection of an outbreak Kpp isolate showing antimicrobial resistance to six antibiotics. Human infection with Kpp ST25 has not been reported in the UK.

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Citations

Dec 30, 2020·Journal of Global Antimicrobial Resistance·Ann-Kathrin KriegerChristoph Georg Baums
Jan 21, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Golnaz MobasseriCindy Shuan Ju Teh
Feb 14, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Jesús Silva-SanchezUlises Garza-Ramos

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Datasets Mentioned

BETA
AF025795
ERS1069962
ERS1069963
ERS1069964
ERS1069966
ERS1069968
ERS1069969
ERS1080571
AF025795.1

Methods Mentioned

BETA
PCR

Software Mentioned

BLAST
PHAST

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