Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis

International Journal of Antimicrobial Agents
Ana C GalesAfonso L Barth

Abstract

We report the first linezolid-resistant Staphylococcus aureus strain isolated in Brazil. The strain was isolated from a 10-year-old female patient with cystic fibrosis (CF) who received repeated and prolonged courses of low-dose linezolid. The strain belonged to the Brazilian endemic methicillin-resistant S. aureus clone, and the G2576U mutation was identified in domain V of the 23S rRNA. Detection of this mechanism of resistance in a CF patient is very worrisome, as these patients may become a reservoir for further dissemination of resistant strains. Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance.

Citations

Jun 5, 2012·Journal of Microbiological Methods·Shinichiro YamachikaHiroyuki Takase
Jul 21, 2012·The Journal of Biological Chemistry·Andrew L LoveringNatalie C J Strynadka
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Venkata G Meka, Howard S Gold
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brian A PotoskiDavid L Paterson
Apr 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea EndimianiRobert A Bonomo
Sep 6, 2012·The Journal of Antimicrobial Chemotherapy·Bing GuRomney M Humphries
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·Silke BesierThomas A Wichelhaus
Feb 24, 2010·Antimicrobial Agents and Chemotherapy·Carmen BetriuJuan J Picazo
Apr 27, 2011·Antimicrobial Agents and Chemotherapy·Rebecca A KeelJoseph L Kuti
Jun 26, 2009·Annals of Clinical Microbiology and Antimicrobials·Floriana CampanileStefania Stefani
Nov 13, 2008·Paediatric Drugs·Jason G Newland, Gregory L Kearns
Jun 2, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Rodrigo E MendesRonald N Jones
Feb 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Russell J BenefieldIgor Z Abolnik
Jan 12, 2016·Expert Opinion on Drug Metabolism & Toxicology·Kristin E LinderMichael D Nailor
Jul 9, 2013·Expert Opinion on Drug Discovery·Michio KurosuKatsuhiko Mitachi
Feb 23, 2010·Clinical Therapeutics·Elena ChiappiniMaurizio de Martino
Nov 17, 2009·Diagnostic Microbiology and Infectious Disease·David J FarrellRonald N Jones
Nov 17, 2009·Diagnostic Microbiology and Infectious Disease·Ronald N JonesJohn D Turnidge
Jul 28, 2009·Diagnostic Microbiology and Infectious Disease·Juan J PicazoUNKNOWN VIRA Study Group
Jun 9, 2009·Diagnostic Microbiology and Infectious Disease·Ronald N JonesKatsunori Yanagihara
Apr 21, 2009·International Journal of Antimicrobial Agents·Nilton LincopanElsa M Mamizuka
Nov 22, 2008·Diagnostic Microbiology and Infectious Disease·Ronald N JonesRodrigo E Mendes
Jun 28, 2007·Pharmacotherapy·Thomas P Lodise, Peggy S McKinnon
Dec 24, 2011·Annals of the New York Academy of Sciences·Karen Joy Shaw, Michael R Barbachyn
Aug 1, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Thiago André CidralMaria Celeste Nunes de Melo
Dec 29, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mustafa SacarHuseyin Turgut
Jan 29, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·John DotisEmmanuel Roilides
Jun 4, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Anne FilleronHélène Marchandin
Oct 21, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sertan GoktasAbdulkadir Bukus
May 15, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S NguyenE Senneville
Dec 3, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E Bouza
Dec 17, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Caínzos

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