Abstract
Macrolide-resistant Mycoplasma pneumoniae (MRMP) is rapidly emerging in Asia, but information on the temporal relationship between the increase in macrolide resistance and changes in strain types is scarce. Between 2011 and 2014, M. pneumoniae infection was diagnosed by PCR as part of routine care in a health care region in Hong Kong. Testing was initiated by clinicians, mainly in patients with suspected M. pneumoniae pneumonia. Specimens positive for M. pneumoniae were retrospectively investigated by macrolide resistance genotyping and a four-locus (Mpn13 to -16) multilocus variable-number tandem-repeat analysis (MLVA) scheme. The overall percentage of M. pneumoniae-positive specimens was 17.9%, with annual rates ranging from 9.8% to 27.2%. The prevalence of MRMP had rapidly increased from 13.6% in 2011 to 30.7% in 2012, 36.6% in 2013, and 47.1% in 2014 (P = 0.038). Two major MLVA types, 4-5-7-2 and 3-5-6-2, accounted for 75% to 85% of the infections each year. MLVA types 4-5-7-2 and 3-5-6-2 predominated among macrolide-resistant and macrolide-sensitive groups, respectively. The increase in MRMP was mainly caused by increasing macrolide resistance in the prevalent MLVA type 4-5-7-2, changing from 25.0% in 2011 to 59.1% in 2012...Continue Reading
References
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN American Thoracic Society
Feb 11, 2009·Journal of Clinical Microbiology·S DégrangeC M Bébéar
Mar 26, 2009·Thorax·D OnozukaA Hagihara
Jun 28, 2011·Journal of Microbiological Methods·Roger Dumke, Enno Jacobs
Aug 9, 2011·World Journal of Pediatrics : WJP·Ying-Chun XuZhi-Min Chen
Sep 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John S BradleyUNKNOWN Pediatric Infectious Diseases Society and the Infectious Diseases Society of America
Jun 1, 2012·Journal of Clinical Microbiology·Yang LiuMinggui Wang
Sep 7, 2012·Journal of Clinical Microbiology·Alvaro J BenitezJonas M Winchell
Sep 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Takafumi OkadaKimiko Ubukata
Nov 22, 2012·The Journal of Antimicrobial Chemotherapy·Nicola Principi, Susanna Esposito
Dec 12, 2012·Journal of Clinical Microbiology·Fei ZhaoJianzhong Zhang
Jan 3, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S PereyreC Bébéar
May 31, 2013·Journal of Clinical Microbiology·Kwok-Hung ChanPak-Leung Ho
Jun 6, 2013·PloS One·Hongmei SunZhaoyang Fan
Jul 24, 2013·Emerging Infectious Diseases·Ki Bae HongJoon-Ho Lee
Nov 28, 2013·Antimicrobial Agents and Chemotherapy·Yunlian ZhouZhimin Chen
Dec 25, 2013·PloS One·Jiuxin QuChen Wang
Feb 28, 2014·Journal of Clinical Microbiology·Guanhua XueHongmei Sun
Sep 5, 2014·Influenza and Other Respiratory Viruses·Susan S ChiuEunice L Y Chan
Sep 19, 2014·Journal of Clinical Microbiology·Chao YanShaoli Li
Oct 31, 2014·Journal of Clinical Microbiology·Maureen H DiazJonas M Winchell
Jan 4, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kai-Ning CheongPak-Leung Ho
Feb 20, 2015·Emerging Infectious Diseases·Roger DumkeUNKNOWN Capnetz Study Group
Jul 1, 2015·Korean journal of pediatrics·Eun-Kyung KimKyung-Yil Lee
Citations
Mar 26, 2016·Frontiers in Microbiology·Maureen H Diaz, Jonas M Winchell
Jul 26, 2016·Frontiers in Microbiology·Sabine PereyreCécile Bébéar
Nov 3, 2017·Japanese Journal of Infectious Diseases·Yu SuzukiYoko Matsuzaki
Aug 24, 2018·PloS One·Guanhua XueHongmei Sun
May 26, 2017·Clinical Microbiology Reviews·Ken B WaitesT Prescott Atkinson
Apr 2, 2019·Journal of Medical Microbiology·Yu SuzukiYoko Matsuzaki
May 24, 2019·Pediatric Pulmonology·Chao YanHongmei Sun
May 24, 2019·Journal of Clinical Pharmacy and Therapeutics·Xiaojiao DuanZiqi Meng
Dec 22, 2019·Pathogens·Roger DumkeTobias Glaunsinger
Sep 3, 2019·Japanese Journal of Infectious Diseases·Chao YanShanshan Ni
Sep 24, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Narjes Noori GoodarziAkram Baghani
Oct 28, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Elena N VoroninaMaxim L Filipenko
Jul 13, 2020·The Journal of Antimicrobial Chemotherapy·Belén RivayaLurdes Matas
Aug 21, 2020·Journal of Clinical Microbiology·L XiaoK B Waites
Jan 27, 2019·PloS One·Chihiro KatsukawaKazuo Takahashi
Jul 14, 2017·Pneumonia·Nguyen T K PhuongBen J Marais
Jun 9, 2017·BMC Infectious Diseases·In Ae YoonEun Hwa Choi
Jul 18, 2018·Emerging Infectious Diseases·Joon Kee LeeEun Hwa Choi
Oct 24, 2019·BMC Infectious Diseases·Wen-Zeng ZhangDan Wu
Sep 28, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R KogojD Keše
May 30, 2020·Open Forum Infectious Diseases·Grace LuiMargaret Ip
Mar 26, 2021·Medicine·Mian WangJie Liu
May 16, 2021·Journal of Microbiological Methods·Roger Dumke, Nadia Rodriguez
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Yacui WangAdong Shen