Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans

Frontiers in Public Health
Nikola Sklenovská, Marc Van Ranst

Abstract

Monkeypox is an emerging zoonotic disease recognized as the most important orthopoxvirus infection in humans in the smallpox post-eradication era. The clinical presentation of monkeypox is similar to the one of smallpox. The case fatality rate of monkeypox (10%) lies between the case fatality rate of variola major (30%) and variola minor (1%). The disease is endemic in the Democratic Republic of the Congo, but other countries of Central and West Africa either reported cases of monkeypox in humans or circulation in wildlife. The disease was also imported once into the USA. The disease has always been considered rare and self-limiting, however recent sporadic reports suggest otherwise. Unfortunately, the collected data is limited, dispersed and often incomplete. Therefore, the objective of this review is to trace all reported human monkeypox outbreaks and relevant epidemiological information. The frequency and geographical spread of human monkeypox cases have increased in recent years, and there are huge gaps in our understanding of the disease's emergence, epidemiology, and ecology. The monkeypox virus is considered a high threat pathogen causing a disease of public health importance. Therefore, there is an urgent need to focus ...Continue Reading

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Apr 18, 2019·Clinical and Experimental Immunology·B AfroughR Hewson
Jun 20, 2019·Emerging Infectious Diseases·Camille BesombesEmmanuel Nakouné
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Methods Mentioned

BETA
PCR

Software Mentioned

One
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