Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.

Emerging Microbes & Infections
João PerdigãoIsabel Portugal

Abstract

The Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Nevertheless, recent data shows that this genotype might be gradually emerging in these two countries as an underlying cause of primary MDR-TB. Here, we describe the emergence of Mycobacterium tuberculosis Beijing strains associated with MDR-TB in Portugal and Guinea-Bissau demonstrating the presence of the well described superclusters 100-32 and 94-32 in Portugal and Guinea-Bissau, respectively. Genome-wide analysis and comparison with a global genomic dataset of M. tuberculosis Beijing strains, revealed the presence of two genomic clusters encompassing isolates from Portugal and Guinea-Bissau, GC1 (n = 121) and GC2 (n = 39), both of which bore SNP signatures compatible with the 100-32/B0/W148 and 94-32/Central Asia Outbreak clades, respectively. Moreover, GC2 encompasses a cross-border cluster between Portugal, Guinea-Bissau and Brazil thus supporting migration-associated introduction of MDR-TB and subsequent clonal expan...Continue Reading

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Citations

Jun 6, 2021·Tuberculosis·Amel Kevin Alame EmaneShengyuan Liu
Aug 10, 2021·Frontiers in Public Health·Prince AsareDorothy Yeboah-Manu
Nov 14, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S M Shahriar RizviS M Mostofa Kamal

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Datasets Mentioned

BETA
ERP002611
PT000080

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

R
Phyloviz
SAMtools
Interactive Tree of Life
R package phangorn
GATK
goeBURST
Seaview
PhyML
BWA

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