PMID: 6989241Jan 1, 1980Paper

Emergence of multiple antibiotic resistance during the therapy of Klebsiella pneumoniae meningitis

The American Journal of the Medical Sciences
S L Barriere, J E Conte

Abstract

A patient is described in whom multiple antibiotic resistance developed during the course of therapy of Klebsiella pneumoniae meningitis. Sequential resistance developed to chloramphenicol, gentamicin and eventually amikacin. As previously reported, the use of the chloramphenicol alone in the therapy of gram-negative bacillary meningitis can result in rapid emergence of resistance and treatment failure. In this patient, the subsequent emergence of gentamicin and amikacin resistance may have been related to the omission of intrathecal aminoglycoside. A short review of the literature is presented and recommendations are made for the therapy of gram-negative bacillary meningitis.

References

Jan 31, 1976·Lancet·R H George, D E Healing
Jun 25, 1977·Lancet·C S BlockC M Lewer-Allen
Dec 11, 1975·The New England Journal of Medicine·A B Kaiser, Z A McGee
Dec 1, 1975·The American Journal of Medicine·R J MangiV T Andriole
Aug 1, 1972·Annals of Internal Medicine·J J Rahal
Jan 9, 1969·The New England Journal of Medicine·L D Sabath
Dec 1, 1971·The Journal of Infectious Diseases·L J Riff, G G Jackson

Citations

May 4, 2004·The Annals of Pharmacotherapy·Kimberly A CorpusChristopher R Zimmerman
Jan 1, 1988·The American Journal of the Medical Sciences·C D Holder, D Halkias

Related Concepts

A.M.K
Antibiotics
Blood
Cerebrospinal Fluid
Syntomycin
Antibiotic Resistance, Microbial
Gentacycol
Intravenous Injections
Intrathecal Injection
Klebsiella Infections

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.