Emergence of Parechovirus A4 Central Nervous System Infections among Infants in Kansas City, Missouri, USA

Journal of Clinical Microbiology
A SasidharanRangaraj Selvarangan

Abstract

Among known parechovirus (PeV) types infecting humans, PeV-A3 (formerly HPeV3) and PeV-A1 (formerly HPeV1) are associated with pediatric central nervous system (CNS) infections. The prevalence of PeV-A3 among hospitalized infants with sepsis-like illness and viral CNS infection is well described; however, the contribution of PeV-A4 to infant CNS infection is relatively unexplored. We report the first 11 U.S. cases of PeV-A4 CNS infections occurring in Kansas City infants during 2010 to 2016 and compare the clinical presentation with that of PeV-A3. PeV-positive cerebrospinal fluid (CSF) specimens from 2010 to 2016 underwent sequencing for genotyping. Among all PeV-CSF positives, PeV-A4 was detected in 11 CSF samples from 2010 to 2016. PeV-A4 was first detected in 2010 (n = 1/4), followed by detections in 2014 (n = 1/39), 2015 (n = 6/9), and 2016 (n = 3/33). The median age of PeV-A4-infected infants in weeks (median, 4; range, 1 to 8) was similar to that of infants infected with PeV-A3 (median, 4; range, 0.25 to 8). Clinical characteristics of PeV-A4 (n = 11) were compared with those of select PeV-A3-infected children (n = 34) with CNS infections and found to be mostly similar, although maximum temperature was higher (P = 0.017)...Continue Reading

References

Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K S M BenschopK C Wolthers
Dec 21, 2006·Emerging Infectious Diseases·Kimberley S M BenschopKatja C Wolthers
Feb 19, 2008·The Pediatric Infectious Disease Journal·Malgorzata A Verboon-MaciolekAnton M van Loon
Jun 19, 2009·The Pediatric Infectious Disease Journal·Dasja PajkrtKatja C Wolthers
May 18, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W Allan NixM Steven Oberste
Oct 16, 2010·The Pediatric Infectious Disease Journal·Rangaraj SelvaranganChristopher J Harrison
Jul 9, 2011·Advances in Pediatrics·José R Romero, Rangaraj Selvarangan
Aug 5, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Beth WaltersXiaotian Zheng
May 23, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Isabelle SchuffeneckerFlorence Morfin
Jul 23, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anne J JääskeläinenMaija Lappalainen
Nov 2, 2014·The Pediatric Infectious Disease Journal·Pekka KolehmainenSisko Tauriainen
Nov 27, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·V A JanesK S Benschop
Jul 17, 2015·The Pediatric Infectious Disease Journal·Katharina KarschBarbara Rath
Sep 4, 2015·MMWR. Morbidity and Mortality Weekly Report·Glen R AbediSusan I Gerber
May 9, 2016·European Journal of Pediatrics·S C M de CromC C Obihara
Apr 4, 2017·Journal of the Pediatric Infectious Diseases Society·Claire M MidgleyJohn T Watson
Aug 2, 2017·The Pediatric Infectious Disease Journal·Eveline P de JongFrank Brus
Dec 6, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Kentaro SanoJun-Ichi Takanashi
May 11, 2018·MMWR. Morbidity and Mortality Weekly Report·Glen R AbediSusan I Gerber

❮ Previous
Next ❯

Citations

Nov 11, 2020·Journal of Medical Microbiology·Katsumi MizutaTatsuya Ikeda
Jul 12, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Teemu SmuraAnne J Jääskeläinen

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.