PMID: 9533727Apr 9, 1998Paper

Emergence of penicillin resistance in recurrent pneumococcal endocarditis in an HIV-infected patient

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
C Gonzaga, L L Dever

Abstract

The emergence of antibiotic resistance in Streptococcus pneumoniae poses a particular threat to HIV-infected patients. These patients are at increased risk of invasive pneumococcal disease and may respond poorly to pneumococcal vaccination. We describe an HIV-infected patient with recurrent aortic valve endocarditis due to the same serotype of S. pneumoniae (19A) despite appropriate treatment with penicillin and immunoprophylaxis. The pneumococcus responsible for the second episode of endocarditis was susceptible to cefotaxime (MIC of 0.06 microg/ml), but was no longer susceptible to penicillin (MIC of 0.25 microg/ml). The patient was treated successfully with 4 weeks of intravenous ceftriaxone.

References

May 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T L KuhlsD P Fine
May 1, 1994·Antimicrobial Agents and Chemotherapy·M L Fernández GuerreroF Soriano
Jul 8, 1996·Archives of Internal Medicine·M Rodríguez-CréixemsE Bouza
Nov 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S WhitbyM S Bronze
Apr 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·D L Klein
Jul 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·F Baquero

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Citations

Mar 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Siegel, J Timpone
Jan 25, 2014·Case Reports in Infectious Diseases·Shikha ShresthaSamir Pancholy
Oct 21, 1999·Scandinavian Journal of Infectious Diseases·J Lindberg, S Fangel

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