Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

PloS One
Benjamin Bruno PolicicchioCristian Apetrei

Abstract

Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation.

References

Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Evguenia S SvarovskaiaVinay K Pathak
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger
Jan 25, 2008·Journal of Virology·Ivona PandreaCristian Apetrei
Jan 29, 2014·Infectious Disease Reports·Pleuni S Pennings
Oct 31, 2015·Future Microbiology·Nicolas Sluis-CremerRaymond F Schinazi
Feb 10, 2016·Frontiers in Immunology·Benjamin B PolicicchioCristian Apetrei

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Datasets Mentioned

BETA
M19499.1
MG686471-MG686486

Methods Mentioned

BETA
PCR

Software Mentioned

Sequencher

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