Emergence of rules in cell society: differentiation, hierarchy, and stability

Bulletin of Mathematical Biology
C Furusawa, K Kaneko

Abstract

A dynamic model for cell differentiation, where cells with internal chemical reaction dynamics interact with each other and replicate was studied. It led to spontaneous differentiation of cells and determination, as discussed in the isologous diversification. The following features of the differentiation were obtained: (1) hierarchical differentiation from a 'stem' cell to other cell types, with the emergence of the interaction-dependent rules for differentiation; (2) global stability of an ensemble of cells consisting of several cell types, that were sustained by the emergent, autonomous control on the rate of differentiation; (3) existence of several cell colonies with different cell-type distributions. The results provide a novel viewpoint on the origin of a complex cell society, while relevance to some biological problems, especially to the hemopoietic system, is also discussed.

Citations

Sep 6, 2003·Journal of Theoretical Biology·Chikara Furusawa, Kunihiko Kaneko
Dec 1, 2002·Journal of Biological Physics·K Kaneko
Jan 2, 2001·Proceedings. Biological Sciences·K Kaneko, T Yomo
May 12, 2001·Artificial Life·C Furusawa, K Kaneko
Aug 16, 2000·Artificial Life·P Hogeweg
May 21, 2008·Artificial Life·Nicholas Geard, Janet Wiles
Jul 5, 2013·PLoS Computational Biology·Koichi Fujimoto, Satoshi Sawai
Oct 16, 2010·Journal of Theoretical Biology·Jan-Ke LarssonRobert Forchheimer
Jun 11, 2008·Journal of Theoretical Biology·Akihiko Nakajima, Kunihiko Kaneko
Jul 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroshi Yoshida, Kunihiko Kaneko
Mar 8, 2005·Journal of Theoretical Biology·Hiroshi YoshidaKunihiko Kaneko
Mar 11, 2005·Journal of Theoretical Biology·Hiroaki Takagi, Kunihiko Kaneko
Aug 6, 1999·Journal of Theoretical Biology·K Kaneko, T Yomo
Feb 20, 2002·Journal of Theoretical Biology·Kunihiko Kaneko, Tetsuya Yomo
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Jul 20, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ricard Solé
Oct 18, 2016·PLoS Computational Biology·Jumpei F YamagishiKunihiko Kaneko
Apr 6, 2001·Physical Review Letters·Y Togashi, K Kaneko
Oct 17, 2002·The Anatomical Record·Chikara Furusawa, Kunihiko Kaneko
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yoshinori Watanabe, Kunihiko Kaneko
Oct 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yusuke Goto, Kunihiko Kaneko
Sep 16, 2000·Physical Review Letters·C Furusawa, K Kaneko
Jun 24, 2021·PLoS Computational Biology·Jumpei F YamagishiKunihiko Kaneko

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