Emergence of subtype Zaire Ebola virus in Gabon

Virology
V VolchkovH Feldmann

Abstract

Gabon has recently been struck three times by Ebola hemorrhagic fever. The first isolate originating from the 1994 outbreak has been subjected to molecular characterization of its GP and VP24 genes. Sequence analysis demonstrates that the agent, Gabon-94 virus, belongs to subtype Zaire of Ebola virus. The isolate is closely related to the Kikwit-95 isolate, and both viruses seem to have evolved from a progenitor virus different from that of the Zaire-76 isolates. The relatively close relationship of all subtype Zaire viruses isolated at different geographical locations and up to 20 years apart suggests an extreme conservation in the yet unknown natural reservoir of Ebola viruses. The level of genetic variability in the human host might be different as indicated by the comparison of isolates from a single outbreak (Mayinga-76 and Eckron-76), but needs further investigation on clinical material of patients by PCR since both isolates have different levels of passages in tissue culture.

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Citations

May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·V E VolchkovH D Klenk
Nov 22, 2012·Viruses·Danielle V ClarkJames V Lawler
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·R N HartyF P Hayes
Sep 18, 2013·Epidemiology and Infection·Y H Li, S P Chen
Aug 4, 2004·The Lancet Infectious Diseases·Siddhartha Mahanty, Mike Bray
Jun 6, 1998·Virology·V E VolchkovH Feldmann
Jan 23, 2020·Journal of Applied Toxicology : JAT·Camille PlantyEric Destexhe
Apr 11, 2006·Clinical and Vaccine Immunology : CVI·Masayuki SaijoShigeru Morikawa
Aug 8, 2021·Current Opinion in Pharmacology·Sanmitra GhoshRudra P Saha

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