Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia.

PLoS Neglected Tropical Diseases
Thi Ty Hang VuCameron P Simmons

Abstract

A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. To this end we determined the complete coding region sequence of 187 DENV-2 genomes and 68 E genes from viruses sampled from Vietnamese patients between 1995 and 2009. Strikingly, an episode of genotype replacement was observed, with Asian 1 lineage viruses entirely displacing the previously dominant Asian/American lineage viruses. This genotype replacement event also seems to have occurred within DENV-2 in Thailand and Cambodia, suggestive of a major difference in viral fitness. To determine the cause of this major evolutionary event we compared both the infectivity of the Asian 1 and Asian/American genotypes in mosquitoes and their viraemia levels in humans. Although there was little difference in infectivity in mosquitoes, we observed significantly higher plasma viraemia levels in paediatric patients infected with Asian 1 lineage viruses relative to Asian/American viruses, a phenotype that is predicted to result in a higher probability of human-to-mosquito transmission. These results provide a mechanistic basis to a marked change in the genetic structure of DENV-2 and more broad...Continue Reading

References

May 1, 1978·The American Journal of Tropical Medicine and Hygiene·D J GublerJ R Hitchcock
Sep 1, 1981·The American Journal of Tropical Medicine and Hygiene·D J GublerS Gunarso
Jul 1, 1997·The American Journal of Tropical Medicine and Hygiene·N SittisombutN Maneekarn
May 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yorgo ModisStephen C Harrison
Jun 18, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S Susanna TwiddyEdward C Holmes
Jun 19, 2003·The American Journal of Tropical Medicine and Hygiene·Philip M Armstrong, Rebeca Rico-Hesse
Aug 2, 2003·Emerging Infectious Diseases·Pallavi GargO Colin Stine
Aug 6, 2003·Emerging Infectious Diseases·William B MesserAravinda M de Silva
Oct 8, 2003·Systematic Biology·Stéphane Guindon, Olivier Gascuel
Dec 23, 2004·Journal of Virology·Raymond ColognaRebeca Rico-Hesse
Jun 15, 2007·Nature Reviews. Microbiology·Stephen S WhiteheadBrian R Murphy
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Oct 8, 2008·Immunological Reviews·Anuja Mathew, Alan L Rothman
Apr 17, 2009·Proceedings. Biological Sciences·Mario ReckerSunetra Gupta

❮ Previous
Next ❯

Citations

Feb 1, 2012·PLoS Neglected Tropical Diseases·Philippe DussartPedro Fernando da Costa Vasconcelos
Mar 11, 2011·PLoS Neglected Tropical Diseases·Annette FoxVan Kinh Nguyen
May 15, 2020·PLoS Neglected Tropical Diseases·Olivia O'ConnorMyrielle Dupont-Rouzeyrol
Mar 18, 2011·The FEBS Journal·Charul GijavanekarRichard C Willson
Jul 9, 2011·Experimental Biology and Medicine·Khoa T D Thai, Katherine L Anders
Aug 13, 2013·PLoS Neglected Tropical Diseases·Maria Rosario CapedingTram Anh Wartel
Sep 16, 2014·PloS One·Md Abu ChoudhuryJohn Aaskov
Oct 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Willem G van PanhuisDerek A T Cummings
Mar 24, 2016·The New England Journal of Medicine·Maïna L'AzouUNKNOWN CYD15 Primary Study Group
Nov 18, 2016·PLoS Computational Biology·Rotem Ben-ShacharKatia Koelle
Jan 30, 2018·PLoS Neglected Tropical Diseases·Josée Castonguay-VanierAudrey Dubot-Pérès
Aug 6, 2020·Viruses·Harapan HarapanAllison Imrie
Jan 8, 2011·The American Journal of Tropical Medicine and Hygiene·Katherine L AndersCameron P Simmons
Oct 21, 2011·Genome Biology·Chiea-Chuen Khor, Martin L Hibberd
May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Minh Nguyen NguyetCameron P Simmons
May 18, 2013·Future Virology·Vivien G DuganElodie Ghedin
Apr 20, 2014·PLoS Neglected Tropical Diseases·Marcio R T NunesW Ian Lipkin
Apr 2, 2014·Virology Journal·Myrielle Dupont-RouzeyrolVan-Mai Cao-Lormeau
Aug 13, 2013·BioMed Research International·Rosmari Rodriguez-Roche, Ernest A Gould
Sep 15, 2015·Evolutionary Applications·Ary A HoffmannGordana Rašić
Apr 11, 2018·Evolutionary Applications·José LourençoMario Recker
May 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ayesa SyeninaEng Eong Ooi
Dec 2, 2011·Journal of Virology·Louis LambrechtsThomas W Scott
Dec 3, 2010·PLoS Neglected Tropical Diseases·José Lourenço, Mario Recker
May 25, 2016·Pathogens and Global Health·Sotianingsih HaryantoR Tedjo Sasmono

❮ Previous
Next ❯

Datasets Mentioned

BETA
EU482654
FM210221

Methods Mentioned

BETA
ELISAs
ELISA
PCR
electrophoresis

Software Mentioned

PHYML
PAUP *
Se
Prism
BEAST
GARLI
Al
STATA
vectorNTI
AlignX

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.