Emergence of the colistin resistance gene mcr-1 and its variant in several uncommon species of Enterobacteriaceae from commercial poultry farm surrounding environments

Veterinary Microbiology
Xiaoming WangShaolin Wang

Abstract

The colistin resistance gene mcr-1 has been detected in multiple members of Enterobacteriaceae family. Here, we report the emergence of mcr-1 in Providencia alcalifaciens and a mcr-1 variant, named mcr-1.3, in Raoultella planticola. Both of the mcr-1-carrying plasmids in these two isolates belong to IncI2 type of plasmids, but they are different in sizes and genetic characteristics. We also detected the mcr-1 gene in one Enterobacter cloacae isolate, however, the mcr-1-carrying plasmid is distinct from the previous reports. Conjugation assay showed that mcr-1-carrying plasmids in P. alcalifaciens and E. cloacae were successfully transferred into recipient E. coli strains. It is worth noting that the transferability of mcr-1-carrying plasmid from E. cloacae was enhanced once it entered into E. coli hosts, which might further accelerate the dissemination of mcr-1 among Enterobacteriaceae. These findings further expand our knowledge of the mcr-1-carrying species in Enterobacteriaceae.

Citations

Feb 12, 2020·International Journal of Environmental Research and Public Health·Madubuike Umunna AnyanwuObichukwu Chisom Nwobi
Oct 13, 2020·Critical Reviews in Microbiology·Shi XiaominWang Shaolin
Jul 3, 2021·Antibiotics·Pedro Miguela-VilloldoMaría Ugarte-Ruiz
Sep 5, 2021·Journal of Applied Microbiology·Ana Beatriz PortesPedro Panzenhagen

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