Emergence of X4 usage among HIV-1 subtype C: evidence for an evolving epidemic in South Africa

AIDS
Bridgette J ConnellMaria A Papathanasopoulos

Abstract

This study investigated the genotype and phenotype of HIV-1 isolates of 20 South African AIDS patients. We found the highest percentage of CXCR4 usage among primary isolates, in which 30% efficiently utilized CXCR4 and exhibited the syncytium-inducing phenotype. Phylogenetic analysis of env confirmed that 19 of the 20 were subtype C, and syncytium-inducing viruses had genetic changes in the V3 loop, characteristic of CXCR4 usage. Results imply that the frequency of CXCR4-utilizing subtype C is increasing with time.

References

Feb 17, 1997·The Journal of Experimental Medicine·R I ConnorN R Landau
Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Nov 20, 2002·Journal of Virology·Grace P McCormackJonathan P Clewley
Jan 13, 2006·Virology·Thumbi Ndung'uMax Essex

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Citations

Mar 26, 2010·AIDS Research and Human Retroviruses·Laura MonnoGioacchino Angarano
Apr 10, 2010·AIDS Research and Human Retroviruses·Muhammad Q FishMaria A Papathanasopoulos
Apr 27, 2013·AIDS Research and Human Retroviruses·Anthony Kebira NyamacheSamoel A Khamadi
Oct 20, 2011·The Journal of Antimicrobial Chemotherapy·Elena DelgadoLucía Pérez-Álvarez
Apr 3, 2009·Current Opinion in HIV and AIDS·John P Moore, Daniel R Kuritzkes
Apr 3, 2009·Current Opinion in HIV and AIDS·Donald E Mosier
Dec 22, 2010·AIDS·Rebecca R GrayMaureen M Goodenow
Feb 25, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nina H LinDaniel R Kuritzkes
Feb 10, 2011·Journal of Translational Medicine·Hanneke SchuitemakerPaolo Lusso
Jun 8, 2010·BMC Research Notes·Svenja PolzerMichael Schreiber
Nov 6, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Soham GuptaAnita Shet
Dec 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stéphanie RaymondJacques Izopet
Jul 27, 2012·Current Opinion in HIV and AIDS·Martin ObermeierAnnemarie M J Wensing
Mar 19, 2014·Critical Reviews in Microbiology·George Panos, Dionysios Christos Watson
Nov 6, 2009·Expert Opinion on Investigational Drugs·Tim KümmerleGerd Fätkenheuer
Feb 26, 2015·Scientific Reports·Kieran CashinPaul R Gorry
Sep 29, 2020·Scientific Reports·Bridgette J ConnellMonique Nijhuis
Apr 9, 2009·Molecular Diagnosis & Therapy·Abraham Joseph KandathilGopalan Sridharan

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