Emergency donor heart protection: application of the port access catheter technique using a pig heart transplantation model

Albertus M ScheuleGerhard Ziemer


Organ shortage limits the number of transplantations, and donor deterioration may precede and often prevent conventional organ preservation. This study evaluates in situ perfusion as a bedside method for cardiac allograft procurement in a large animal model. Thirty Landrace pigs (42 +/- 7 kg) were studied. The hearts in the conventional group underwent cardioplegic arrest with University of Wisconsin solution and sodium-hydrogen exchange inhibitor cariporide as an additive; they were explanted and stored on ice before transplantation. In the in situ group, one catheter was placed in the ascending aorta and another in the right atrium. After disconnection from the ventilator, hypoxia caused circulatory arrest. The aorta was endoclamped, and in situ perfusion of the aortic root was maintained with University of Wisconsin solution and cariporide. After explantation, hearts were stored on ice for 120 min. All hearts were implanted according to the Shumway technique. Ventricular pressure and cardiac output were monitored online, and troponin-I was measured intermittently. Two hours after weaning from extracorporal circulation, the animals were killed and histology was performed. Catheters were placed through introducers within 5 min...Continue Reading


May 1, 1992·The Annals of Thoracic Surgery·S R GundryL L Bailey
Jul 1, 1996·The Annals of Thoracic Surgery·M C MauneyC G Tribble
Jun 1, 1997·The Annals of Thoracic Surgery·J T CopeC G Tribble
Jan 1, 1997·Transplant International : Official Journal of the European Society for Organ Transplantation·J H DaemenG Kootstra
Aug 1, 1997·Journal of Cardiovascular Pharmacology·H H KleinK Nebendahl
Jan 1, 1998·Transplantation Proceedings·J A LightJ D Harviel
Jan 1, 1998·Transplantation Proceedings·G Kootstra
Jan 1, 1997·British Medical Bulletin·G KootstraE Heineman
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J MartinF Beyersdorf
Mar 27, 2001·Transplantation Proceedings·A M ScheuleG Ziemer
Jun 11, 2003·Journal of Medical Ethics·N ZamperettiC Ronco
Aug 12, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan Rhys David CropperPeter Simon Macdonald
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Steven W BoyceUNKNOWN GUARD During Ischemia Against Necrosis (GUARDIAN) Study Investigators
Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Albertus M ScheuleGerhard Ziemer

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Aug 16, 2008·The New England Journal of Medicine·Mark M BoucekUNKNOWN Denver Children's Pediatric Heart Transplant Team
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