Emergency Management of Malignancy-Associated Hypercalcemia

Advanced Emergency Nursing Journal
Bethany Dellay, Meghan Groth

Abstract

The most common cause of hypercalcemia in the emergency department (ED) is malignancy-associated hypercalcemia (MAH), which can be caused by direct bone resorption from bone metastases, vitamin D secreting malignancies, and increased parathyroid hormone (PTH) or PTH-related protein (PTHrP) levels. Malignancy-associated hypercalcemia is associated with a very poor prognosis, with half of the patients dying within a month of diagnosis. Management consists of adequate hydration, bisphosphonate therapy, and correction of other abnormal electrolyte levels. Currently, no therapies have demonstrated an effect on mortality and are therefore viewed only as a means of stabilizing the patient until the underlying condition can be treated. All MAH patients should receive an oncology consult as soon as possible so they are able to receive treatment for the causative malignancy and increase their chance of survival.

References

Apr 30, 1992·The New England Journal of Medicine·J P Bilezikian
Jan 1, 1993·Scandinavian Journal of Urology and Nephrology·A DavenportJ C Mackenzie
Apr 1, 1997·Journal of Clinical Pharmacology·J R BerensonJ J Seaman
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P MajorJ Seaman
Jan 28, 2005·The New England Journal of Medicine·Andrew F Stewart
Mar 16, 2006·The American Journal of the Medical Sciences·Chien-Te LeeHung-Chun Chen
Aug 20, 2008·Annals of Internal Medicine·Susan B LeGrandIvan Zama
Jun 14, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·Rachel Crowley, Neil Gittoes
Jul 15, 2015·Clinical Therapeutics·Matthew T DrakeE Michael Lewiecki

❮ Previous
Next ❯

Citations

Dec 30, 2017·Experimental and Therapeutic Medicine·Runying ZouXiangling He
Apr 17, 2021·Journal of Clinical Pathology·María Julia MartínClaudia Gentili

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Asian Pacific Journal of Cancer Prevention : APJCP
Bassam Abdul Rasool HassanElisabete Weiderpass
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Gideon A Rodan
© 2021 Meta ULC. All rights reserved