Emergency postexposure vaccination with vesicular stomatitis virus-vectored Ebola vaccine after needlestick

JAMA : the Journal of the American Medical Association
Lilin LaiMark J Mulligan

Abstract

Safe and effective vaccines and drugs are needed for the prevention and treatment of Ebola virus disease, including following a potentially high-risk exposure such as a needlestick. To assess response to postexposure vaccination in a health care worker who was exposed to the Ebola virus. Case report of a physician who experienced a needlestick while working in an Ebola treatment unit in Sierra Leone on September 26, 2014. Medical evacuation to the United States was rapidly initiated. Given the concern about potentially lethal Ebola virus disease, the patient was offered, and provided his consent for, postexposure vaccination with an experimental vaccine available through an emergency Investigational New Drug application. He was vaccinated on September 28, 2014. The vaccine used was VSVΔG-ZEBOV, a replicating, attenuated, recombinant vesicular stomatitis virus (serotype Indiana) whose surface glycoprotein gene was replaced by the Zaire Ebola virus glycoprotein gene. This vaccine has entered a clinical trial for the prevention of Ebola in West Africa. The vaccine was administered 43 hours after the needlestick occurred. Fever and moderate to severe symptoms developed 12 hours after vaccination and diminished over 3 to 4 days. The...Continue Reading

Citations

Jul 1, 2015·Pathology·Jen KokSharon C-A Chen
Jun 13, 2015·Expert Opinion on Investigational Drugs·Gary Wong, Xiangguo Qiu
Jan 18, 2016·Enfermedades infecciosas y microbiología clínica·Fernando de la Calle-PrietoJose Ramon Arribas
Nov 14, 2015·The Journal of Infectious Diseases·Marianne ArnemoTor Gjøen
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Miran BlanchardRichard Vile
Sep 1, 2015·The Lancet Infectious Diseases·Mark J Mulligan, Paul N Siebert
Mar 25, 2016·Expert Review of Vaccines·Robert A Kozak, Gary P Kobinger
May 8, 2015·ACS Infectious Diseases·Andrea Rivera, Ilhem Messaoudi
Mar 31, 2015·Lancet·Andrea Marzi, Darryl Falzarano
Apr 21, 2016·Cellular and Molecular Life Sciences : CMLS·Yuanwu LiuXiangdong Li
Apr 14, 2015·Infectious Diseases of Poverty·Haider GhazanfarAli Ghazanfar
Apr 2, 2015·The New England Journal of Medicine·Selidji T AgnandjiClaire-Anne Siegrist
Apr 28, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen K WongTimothy M Uyeki
Jul 23, 2016·The Journal of Infectious Diseases·Pauline VetterLaurent Kaiser
Oct 21, 2016·Human Vaccines & Immunotherapeutics·Yuxiao WangFengcai Zhu
Jan 13, 2017·PLoS Pathogens·Keith J Chappell, Daniel Watterson
Jan 12, 2017·The Journal of Infectious Diseases·Frederick G HaydenDaniel G Bausch
Dec 17, 2015·Therapeutic Advances in Vaccines·Saranya Sridhar
Jan 30, 2018·Nature Reviews. Drug Discovery·Robert W CrossThomas W Geisbert
May 15, 2015·Clinical Microbiology Reviews·Gary Wong, Gary P Kobinger
Feb 7, 2019·Health Security·Nahid BhadeliaUNKNOWN National Ebola Training and Education Center's Special Pathogens Research Network (SPRN)'s Medical Countermeasures Working G
Aug 2, 2019·Human Vaccines & Immunotherapeutics·Anahita FathiMarylyn M Addo
Dec 1, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chris DavisEmma C Thomson
Jul 30, 2016·Critical Care : the Official Journal of the Critical Care Forum·Aleksandra LeligdowiczRobert A Fowler
Nov 5, 2019·Epidemiologic Reviews·Tara Gallagher, Marc Lipsitch
Nov 18, 2017·Expert Opinion on Biological Therapy·Gary WongXiangguo Qiu
Aug 14, 2020·Nature·Mark J MulliganKathrin U Jansen
Jul 9, 2016·MMWR Supplements·Chris A Van BenedenBeth P Bell
Sep 17, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Colleen S KraftUNKNOWN Serious Communicable Diseases Unit (SCDU)
Oct 1, 2016·Annual Review of Medicine·Rohan KeshwaraMatthias J Schnell
Apr 14, 2017·Science Translational Medicine·Angela HuttnerClaire-Anne Siegrist
Jun 24, 2016·Microbiology Spectrum·Robert Fisher, Luciana Borio
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber
Dec 10, 2021·PLoS Pathogens·Courtney Woolsey, Thomas W Geisbert

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.