Emergency resection surgery for colorectal cancer: Patterns of recurrent disease and survival

World Journal of Gastrointestinal Pathophysiology
Joe LittlechildDarren Subar

Abstract

To evaluate prognostic pathological factors associated with early metachronous disease and adverse long-term survival in these patients. Clinical and histological features were analysed retrospectively over an eight-year period for prognostic impact on recurrent disease and overall survival in patients undergoing curative resection of a primary colorectal cancer. A total of 266 patients underwent curative surgery during the study period. The median age of the study cohort was 68 year (range 26 to 91) with a follow-up of 7.9 years (range 4.6 to 12.6). Resection was undertaken electively in 225 (84.6%) patients and emergency resection in 35 (13.2%). Data on timing of surgery was missing in 6 patients. Recurrence was noted in 67 (25.2%) during the study period and was predominantly early within 3 years (82.1%) and involved hepatic metastasis in 73.1%. Emergency resection (OR = 3.60,P= 0.001), T4 stage (OR = 4.33,P< 0.001) and lymphovascular invasion (LVI) (OR = 2.37,P= 0.032) were associated with higher risk of recurrent disease. Emergency resection, T4 disease and a high lymph node ratio (LNR) were strong independent predictors of adverse long-term survival. Emergency surgery is associated with adverse disease free and long-term ...Continue Reading

References

Nov 1, 1979·Diseases of the Colon and Rectum·P M McCormack, F F Attiyeh
Nov 1, 1990·The British Journal of Surgery·J ScheeleA Altendorf-Hofmann
Feb 1, 1994·Annals of Surgery·D J BruinvelsC J van de Velde
Jan 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·U PastorinoUNKNOWN International Registry of Lung Metastases
May 1, 1997·Archives of Surgery·R L JamisonD M Ilstrup
Feb 9, 2000·Lancet·J M BermanD S Weinberg
Oct 8, 2003·BMC Cancer·Alvaro FigueredoUNKNOWN Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
Oct 10, 2003·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Ricardo VallejoShihab Ahmed
Apr 6, 2004·The Surgical Clinics of North America·René AdamHenri Bismuth
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentAimery De Gramont
Nov 14, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H Z MalikJ P A Lodge
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M JefferyP N Hider
Mar 10, 2007·Diseases of the Colon and Rectum·Ariella Bar-Gil ShitritMordechai R Kramer
Dec 22, 2007·Diseases of the Colon and Rectum·Siu Kin C WongStephen B Fulham
Jun 14, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G LurjeH-J Lenz
Dec 17, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ker Kan TanRichard Sim
Aug 1, 2005·Clinics in Colon and Rectal Surgery·Ron G Landmann, Martin R Weiser
Nov 1, 2006·Clinics in Colon and Rectal Surgery·Michael D Hellinger, Cesar A Santiago
Feb 2, 2010·Journal of the Royal Society of Medicine·Francesca FiorentinoMartin Utley
Mar 23, 2010·Diseases of the Colon and Rectum·Seok-Byung LimJin Cheon Kim
Jul 16, 2010·The British Journal of Surgery·E J A MorrisG Poston
Jul 7, 2011·Diseases of the Colon and Rectum·Bilgi BacaDavid A Etzioni
Mar 14, 2012·Journal of the Korean Society of Coloproctology·Min Ae KeumJin Cheon Kim
Sep 13, 2012·Experimental and Therapeutic Medicine·Hiroaki NozawaJoji Kitayama
Oct 16, 2012·The Annals of Thoracic Surgery·Shanda H BlackmonAra A Vaporciyan
Mar 19, 2013·International Journal of Colorectal Disease·Jung Wook HuhYoung Jin Kim
Jun 14, 2013·World Journal of Surgical Oncology·Sam GhaziUNKNOWN Low-Risk Colorectal Cancer Study Group
Nov 14, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtUNKNOWN American Society of Clinical Oncology
Jan 17, 2014·JAMA : the Journal of the American Medical Association·John N PrimroseUNKNOWN FACS Trial Investigators
Mar 4, 2014·World Journal of Gastroenterology : WJG·Johnie RoseGregory S Cooper
Jan 17, 2015·International Surgery·John HoganJohn Calvin Coffey

❮ Previous
Next ❯

Citations

Jun 9, 2019·Nature Reviews. Drug Discovery·Aran F LabrijnPaul W H I Parren
Aug 17, 2021·Current Problems in Surgery·Nicholas FarkasMirza Khurrum Baig

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.